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Gisela Brändén

Associate senior lecturer

Gisela Brändén
Associate senior lecturer
Academic degree: Doctor
gisela.branden@gu.se
+46 31 786 3915

Room number: 1212
Postal Address: Box 462, 40530 Göteborg
Visiting Address: Medicinaregatan 9C , 41390 Göteborg


Department of Chemistry & Molecular Biology (More Information)
Box 462
405 30 Göteborg
www.cmb.gu.se
inst.kmb@cmb.gu.se
Fax: +46 31 786 2599

Visiting Address: Medicinaregatan 9 C , 405 30 Göteborg

About Gisela Brändén

I am a structural biochemist with a pharmaceutical industry background. Since a few years back I am now leading a research group at the Department of Chemistry and Molecular Biology at the University of Gothenburg.


The focus of my research group is to study the structure, function and dynamics of membrane proteins. We use a combination of different biochemical and biophysical methods to describe proteins in detail as they work, including X-ray crystallography, absorbance spectroscopy, WAXS (Wide-Angle X-ray Scattering) and X-ray Free Electron Laser (XFEL) coherent diffractive imaging. We put a lot of effort into development of time resolved synchrotron- and XFEL-based methods. Using these methods we investigate the energy converting systems of the cell, more specifically cytochrome oxidase of the respiratory chain and bacterial photosynthetic reaction center. In addition we use microtubules, the major constituent of the cytoskeleton, as a model system for XFEL imaging.


My other area of focus is structure-based drug design. In a collaboration with AstraZeneca we study the membrane-bound protein MraY, essential for bacterial cell wall synthesis. As such, MraY is a very suitable target to overcome the acutely developing problem of antibiotic resistance. Our aim is to describe how MraY interacts with different inhibitors, with the long-term goal to develop a novel antibiotic compounds. In a related research project we study the cytochrome P450s, the main drug-metabolizing system in the body. We believe that a better understanding of the interaction between the cytochrome P450s and different pharmaceutical compounds will lead to fewer side effects of drugs in the future.

Latest publications

From Macrocrystals to Microcrystals: A Strategy for Membrane Protein Serial Crystallography.
Robert Dods, Petra Båth, David Arnlund, Kenneth R Beyerlein, Garrett Nelson et al.
Structure (London, England : 1993), Journal article 2017
Journal article

Flow-aligned, single-shot fiber diffraction using a femtosecond X-ray free-electron laser.
David Popp, N Duane Loh, Habiba Zorgati, Umesh Ghoshdastider, Lu Ting Liow et al.
Cytoskeleton (Hoboken, N.J.), Journal article 2017
Journal article

MraY-antibiotic complex reveals details of tunicamycin mode of action.
Jonna K Hakulinen, Jenny Hering, Gisela Brändén, Hongming Chen, Arjan Snijder et al.
Nature chemical biology, Journal article 2017
Journal article

Membrane protein structural biology using X-ray free electron lasers
Richard Neutze, Gisela Brändén, G.F.X. Schertler
Current Opinion in Structural Biology, Journal article 2015
Journal article

Structure-based ligand design to overcome CYP inhibition in drug discovery projects
Gisela Brändén, T. Sjogren, V. Schnecke, Y. F. Xue
Drug Discovery Today, Review article 2014
Review article

Deuterium isotope effect of proton pumping in cytochrome c oxidase
Lina Salomonsson, Gisela Brändén, Peter Brzezinski
Biochimica et Biophysica Acta, Journal article 2008
Journal article

Structural elements involved in proton translocation by cytochrome c oxidase as revealed by backbone amide hydrogen-deuterium exchange of the E286H mutant
Laura Busenlehner, Gisela Brändén, Ida Namslauer, Peter Brzezinski, Richard Armstrong
Biochemistry, Journal article 2008
Journal article

Controlled uncoupling and re-coupling of proton pumping in cytochrome c oxidase
Gisela Brändén, Ashtamurthy Pawate, Robert Gennis, Peter Brzezinski
Proceedings of the National Academy of Science of the United States of America, Journal article 2006
Journal article

Transmembrane proton translocation by cytochrome c oxidase
Gisela Brändén, Robert Gennis, Peter Brzezinski
Biochimica et Biophysica Acta, Journal article 2006
Journal article

Showing 1 - 10 of 17

2017

From Macrocrystals to Microcrystals: A Strategy for Membrane Protein Serial Crystallography.
Robert Dods, Petra Båth, David Arnlund, Kenneth R Beyerlein, Garrett Nelson et al.
Structure (London, England : 1993), Journal article 2017
Journal article

Flow-aligned, single-shot fiber diffraction using a femtosecond X-ray free-electron laser.
David Popp, N Duane Loh, Habiba Zorgati, Umesh Ghoshdastider, Lu Ting Liow et al.
Cytoskeleton (Hoboken, N.J.), Journal article 2017
Journal article

MraY-antibiotic complex reveals details of tunicamycin mode of action.
Jonna K Hakulinen, Jenny Hering, Gisela Brändén, Hongming Chen, Arjan Snijder et al.
Nature chemical biology, Journal article 2017
Journal article

2015

Membrane protein structural biology using X-ray free electron lasers
Richard Neutze, Gisela Brändén, G.F.X. Schertler
Current Opinion in Structural Biology, Journal article 2015
Journal article

2014

Structure-based ligand design to overcome CYP inhibition in drug discovery projects
Gisela Brändén, T. Sjogren, V. Schnecke, Y. F. Xue
Drug Discovery Today, Review article 2014
Review article

2008

Deuterium isotope effect of proton pumping in cytochrome c oxidase
Lina Salomonsson, Gisela Brändén, Peter Brzezinski
Biochimica et Biophysica Acta, Journal article 2008
Journal article

Structural elements involved in proton translocation by cytochrome c oxidase as revealed by backbone amide hydrogen-deuterium exchange of the E286H mutant
Laura Busenlehner, Gisela Brändén, Ida Namslauer, Peter Brzezinski, Richard Armstrong
Biochemistry, Journal article 2008
Journal article

2006

Controlled uncoupling and re-coupling of proton pumping in cytochrome c oxidase
Gisela Brändén, Ashtamurthy Pawate, Robert Gennis, Peter Brzezinski
Proceedings of the National Academy of Science of the United States of America, Journal article 2006
Journal article

Transmembrane proton translocation by cytochrome c oxidase
Gisela Brändén, Robert Gennis, Peter Brzezinski
Biochimica et Biophysica Acta, Journal article 2006
Journal article

Showing 1 - 10 of 17

Page Manager: Katleen Burm|Last update: 9/20/2013
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