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Per Sunnerhagen

Professor

Per Sunnerhagen
Professor
per.sunnerhagen@cmb.gu.se
+46 31 786 3830

Postal Address: Box 462, 40530 Göteborg
Visiting Address: Medicinaregatan 9C , 41390 Göteborg


Department of Chemistry & Molecular Biology (More Information)
Box 462
405 30 Göteborg
www.cmb.gu.se
inst.kmb@cmb.gu.se
Fax: +46 31 786 2599

Visiting Address: Medicinaregatan 9 C , 405 30 Göteborg

About Per Sunnerhagen

Contact: Lundberg Laboratory, Medicinaregatan 9, room 1413

RESEARCH

Posttranscriptional regulation under stress

A cell uses several mechanisms to deal with the stress imposed by a rapidly changing environment. It has to focus on expressing those particular proteins that enable it to survive the stress, and then quickly readapt to normal conditions.
Regulation on the RNA level (”post-transcriptional regulation”) is both rapid and energy-efficient since it interferes before the energy-demanding process of protein synthesis. Under stress, the cell chooses certain mRNAs for making proteins (translation). We search for the sequence signals in mRNA that control this mechanism, and also the RNA-binding proteins that recognize these signals and direct mRNA to ribosomes for translation.

Stress granules (SGs) constitute a spectacular mechanism used by the cell under severe stress. These are large complexes of RNA and proteins. In SGs, mRNAs remain silent without being translated, in order to later be reactivated when the stress disappears and conditions improve. We identify the genes required for formation of SGs. We want to understand how formation of SGs is organized, and how the cellular signaling pathways control this pathway according to the type of stress. SGs can also affect aspects of cellular life, such as intracellular signaling and apoptosis, which makes SGs significant for cellular responses to cancer therapy.

Antimicrobial resistance

Pathogens resistant to treatment with antimicrobial agents pose a rising global threat. Antibiotics are being overused, misused, and spread into the environment. As a result, genes encoding proteins designated to inactivate antibiotics, as well as mutations in genes encoding target proteins for antibiotics, accumulate in microbial populations. Our group is member of the Centre for antibiotics resistance research at the University of Gothenburg, CARe. We aim at discovering novel antibacterial molecules from natural and synthetic sources. To identify their mode of action and possible synergies with existing antibiotics is a priority. We are also involved in a project to identify genetic factors determining transfer between bacterial cells of plasmids carrying antibiotics resistance genes.

In an international collaboration with partners in Brazil and Cambodia, we search for novel molecules active against drug-resistant Plasmodium, the malaria parasite. Here we use yeast genetic engineering tools to find bioactive molecules selective for the parasite’s proteins over the human counterparts.
 

Research group: Elena Garre (postdoctoral scientist), Heejung Kim (postdoctoral scientist), Johanna Johansson Sjölander (PhD student), Hanna Alalam (PhD student)

 

TEACHING

Cell biology BIO900

Molecular genetics BIO905

Molecular biology BIO545

Molecular biology methods KMG042

The cell and its hereditary material CEB210

Cell physiology CEB220

Drug development BIO523/KMG046 (course examiner)

 

Latest publications

The mRNA cap-binding protein Cbc1 is required for high and timely expression of genes by promoting the accumulation of gene-specific activators at promoters
Tianlu Li, Nikki De Clercq, Daniel Medina, Elena Garré, Per Sunnerhagen et al.
Biochimica et Biophysica Acta. Gene Regulatory Mechanisms, Journal article 2016
Journal article

Stress-induced inhibition of translation independently of eIF2α phosphorylation
Jon Halvor Knutsen, Gro Elise Rødland, Cathrine Arnason Bøe, Tine Weise Håland, Per Sunnerhagen et al.
Journal of Cell Science, Journal article 2015
Journal article

Cytotoxic Quinones from the roots of Aloe dawei
Negera Abdissa, Martha Induli, Paul A. Fitzpatrick, John Patrick Alao, Per Sunnerhagen et al.
Molecules, Journal article 2014
Journal article

Stress granule-defective mutants deregulate stress responsive transcripts
Xiaoxue Yang, Yi Shen, Elena Garré, Xinxin Hao, Daniel Krumlinde et al.
PLoS Genetics, Journal article 2014
Journal article

Flemingins G–O, Cytotoxic and Antioxidant Constituents of the Leaves of Flemingia grahamiana
Ivan Gumula, John Patrick Alao, Isiah Omolo Ndiege, Per Sunnerhagen, Abiy Yenesew et al.
Journal of natural products, Journal article 2014
Journal article

The checkpoint-dependent nuclear accumulation of Rho1p exchange factor Rgf1p is important for tolerance to chronic replication stress
Sofia Muñoz, Elvira Manjón, Patricia García, Per Sunnerhagen, Yolanda Sánchez
Molecular Biology of the Cell, Journal article 2014
Journal article

Caffeine stabilizes Cdc25 independently of Rad3 in Schizosaccharomyces pombe contributing to checkpoint override
John Patrick Alao, Johanna J Sjölander, Juliane Baar, Nejla Özbaki-Yagan, Bianca Kakoschky et al.
Molecular Microbiology, Journal article 2014
Journal article

Azastilbenes: a cut-off to p38 MAPK inhibitors
Jia-Fei Poon, John Patrick Alao, Per Sunnerhagen, Peter Dinér
Organic and biomolecular chemistry, Journal article 2013
Journal article

Showing 1 - 10 of 48

2016

The mRNA cap-binding protein Cbc1 is required for high and timely expression of genes by promoting the accumulation of gene-specific activators at promoters
Tianlu Li, Nikki De Clercq, Daniel Medina, Elena Garré, Per Sunnerhagen et al.
Biochimica et Biophysica Acta. Gene Regulatory Mechanisms, Journal article 2016
Journal article

2015

Stress-induced inhibition of translation independently of eIF2α phosphorylation
Jon Halvor Knutsen, Gro Elise Rødland, Cathrine Arnason Bøe, Tine Weise Håland, Per Sunnerhagen et al.
Journal of Cell Science, Journal article 2015
Journal article

2014

Cytotoxic Quinones from the roots of Aloe dawei
Negera Abdissa, Martha Induli, Paul A. Fitzpatrick, John Patrick Alao, Per Sunnerhagen et al.
Molecules, Journal article 2014
Journal article

Stress granule-defective mutants deregulate stress responsive transcripts
Xiaoxue Yang, Yi Shen, Elena Garré, Xinxin Hao, Daniel Krumlinde et al.
PLoS Genetics, Journal article 2014
Journal article

Flemingins G–O, Cytotoxic and Antioxidant Constituents of the Leaves of Flemingia grahamiana
Ivan Gumula, John Patrick Alao, Isiah Omolo Ndiege, Per Sunnerhagen, Abiy Yenesew et al.
Journal of natural products, Journal article 2014
Journal article

The checkpoint-dependent nuclear accumulation of Rho1p exchange factor Rgf1p is important for tolerance to chronic replication stress
Sofia Muñoz, Elvira Manjón, Patricia García, Per Sunnerhagen, Yolanda Sánchez
Molecular Biology of the Cell, Journal article 2014
Journal article

Caffeine stabilizes Cdc25 independently of Rad3 in Schizosaccharomyces pombe contributing to checkpoint override
John Patrick Alao, Johanna J Sjölander, Juliane Baar, Nejla Özbaki-Yagan, Bianca Kakoschky et al.
Molecular Microbiology, Journal article 2014
Journal article

2013

Azastilbenes: a cut-off to p38 MAPK inhibitors
Jia-Fei Poon, John Patrick Alao, Per Sunnerhagen, Peter Dinér
Organic and biomolecular chemistry, Journal article 2013
Journal article

Showing 1 - 10 of 48

Page Manager: Katleen Burm|Last update: 9/20/2013
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