Contact details: Lundberg Laboratory, Medicinaregatan 9, Room number 1415
Molecular biology of metal toxicity and tolerance
Many metals endanger the environment and human health, but are also increasingly used as therapeutic agents for medical treatment. Yet, little is known about the molecular mechanisms causing metal toxicity or the mechanisms by which eukaryotic cells counteract toxicity and acquire tolerance.
To gain insights into metal action and cellular tolerance mechanisms, we use front-line tools in molecular biology, biochemistry, cell biology, chemical biology and functional genomics. We study (1) transport proteins through which metals enter or leave cells, (2) signal transduction and transcriptional regulatory mechanisms that cells use to sense and respond to metals, and (3) proteins and cellular processes that are targeted by metals. We use the model eukaryote Saccharomyces cerevisiae to explore fundamental aspects of metal biology and also as a heterologous expression system to study tolerance factors from other organisms such as plants and mammals.
Publications ResearcherID: www.researcherid.com/rid/E-8183-2010
Publications Google Scholar: scholar.google.se/citations
Research team: Therese Jacobson (PhD student), Sansan Hua (PhD student), Nallani Vijay Kumar (postdoc)
- Eukaryotic Molecular Microbiology (BIO440)
- Molecular Microbiology (BIO277)
- Cell biology (BIO900)
- Vice Head outreach: Department of Chemistry and Molecular Biology
- Head of course: Eukaryotic Molecular Microbiology (BIO440)
- Chair appointment board (Docenturnämnd): Faculty of Science
Markus J. Tamás studied molecular biology and biochemistry in Lund (Sweden) and Liège (Belgium) and spent a year as a research scholar at the Public Health Research Institute in New York (USA). Markus completed his PhD at the Katholieke Universiteit Leuven (Belgium) in 1999 and then moved to Gothenburg. Markus was awarded an assistant professorship by the Swedish Research Council in 2003 and became professor in eukaryotic microbiology in 2010.