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Markus Tamas

Professor

Markus Tamas
Professor
molecular biology/genetics/biochemistry/yeast
Academic degree: Docent
markus.tamas@cmb.gu.se
Phone: +46 31 7862548
Mobile phone: 0733-732548
Visiting Address: Medicinaregatan 9C, 41390 Göteborg
Room number: 1450
Postal Address: Box 462, 40530 Göteborg


Department of Chemistry & Molecular Biology (More Information)
Box 462
40530 Göteborg
Visiting Address: Medicinaregatan 9 c, 40530 Göteborg
Web Page: www.cmb.gu.se
Email: inst.kmb@cmb.gu.se
Fax: +46 31 7862599

About Markus Tamas

Contact details: Lundberg Laboratory, Medicinaregatan 9, Room number 1415

 

RESEARCH

Molecular biology of metal toxicity and tolerance

Many metals endanger the environment and human health, but are also increasingly used as therapeutic agents for medical treatment. Yet, little is known about the molecular mechanisms causing metal toxicity or the mechanisms by which eukaryotic cells counteract toxicity and acquire tolerance.
To gain insights into metal action and cellular tolerance mechanisms, we use front-line tools in molecular biology, biochemistry, cell biology, chemical biology and functional genomics. We study (1) transport proteins through which metals enter or leave cells, (2) signal transduction and transcriptional regulatory mechanisms that cells use to sense and respond to metals, and (3) proteins and cellular processes that are targeted by metals. We use the model eukaryote Saccharomyces cerevisiae to explore fundamental aspects of metal biology and also as a heterologous expression system to study tolerance factors from other organisms such as plants and mammals.

Publications ResearcherID: www.researcherid.com/rid/E-8183-2010

Publications Google Scholar: scholar.google.se/citations

Research team: Therese Jacobson (PhD student), Sansan Hua (PhD student), Nallani Vijay Kumar (postdoc)


TEACHING

  • Eukaryotic Molecular Microbiology (BIO440)
  • Molecular Microbiology (BIO277)
  • Cell biology (BIO900)

 

COMMISSIONS

  • Vice Head outreach: Department of Chemistry and Molecular Biology
  • Head of course: Eukaryotic Molecular Microbiology (BIO440)
  • Chair appointment board (Docenturnämnd): Faculty of Science

 

QUALIFICATIONS

Markus J. Tamás studied molecular biology and biochemistry in Lund (Sweden) and Liège (Belgium) and spent a year as a research scholar at the Public Health Research Institute in New York (USA). Markus completed his PhD at the Katholieke Universiteit Leuven (Belgium) in 1999 and then moved to Gothenburg. Markus was awarded an assistant professorship by the Swedish Research Council in 2003 and became professor in eukaryotic microbiology in 2010.

Major publications

The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast.
Michael Thorsen, Yujun Di, Carolina Tängemo, Montserrat Morillas, Doryaneh Ahmadpour et al.
Molecular biology of the cell, Volume 17, Issue 10, Pages 4400-10 2006
Journal Article, peer-reviewed

Arsenite interferes with protein folding and triggers formation of protein aggregates in yeast.
Therese Jacobson, Clara Navarrete, Sandeep K Sharma, Theodora C Sideri, Sebastian Ibstedt et al.
Journal of cell science, Volume 125, Issue 21, Pages 5073-83 2012
Journal Article, peer-reviewed

Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8.
Nallani Vijay Kumar, Jianbo Yang, Jitesh K Pillai, Swati Rawat, Carlos Solano et al.
Molecular and cellular biology, Volume 36, Issue 6, Pages 913-22 2015
Journal Article, peer-reviewed

Latest publications

Distinct stress conditions result in aggregation of proteins with similar properties.
Alan J Weids, Sebastian Ibstedt, Markus J. Tamás, Chris M Grant
Scientific reports, Volume 6, Pages 24554 2016
Journal Article, peer-reviewed

Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8.
Nallani Vijay Kumar, Jianbo Yang, Jitesh K Pillai, Swati Rawat, Carlos Solano et al.
Molecular and cellular biology, Volume 36, Issue 6, Pages 913-22 2015
Journal Article, peer-reviewed

HwHog1 kinase activity is crucial for survival of Hortaea werneckii in extremely hyperosmolar environments.
Anja Kejžar, Morten Grøtli, Markus J. Tamás, Ana Plemenitaš, Metka Lenassi
Fungal genetics and biology : FG & B, Volume 74, Pages 45-58 2015
Journal Article, peer-reviewed

Application of a peptide-based assay to characterize inhibitors targeting protein kinases from yeast
Jenny Veide Vilg, S. Dahal, T. Ljungdahl, Morten Grøtli, Markus J. Tamás
Current Genetics, Volume 60, Issue 3, Pages 193-200 2014
Journal Article, peer-reviewed

Mathematical modelling of arsenic transport, distribution and detoxification processes in yeast.
Soheil Rastgou Talemi, Therese Jacobson, Vijay Garla, Clara Navarrete, Annemarie Wagner et al.
Molecular Microbiology, Volume 92, Issue 6, Pages 1343-56 2014
Journal Article, peer-reviewed

Global analysis of protein aggregation in yeast during physiological conditions and arsenite stress.
Sebastian Ibstedt, Theodora C Sideri, Chris M Grant, Markus J. Tamás
Biology open, Volume 3, Issue 10, Pages 913-923 2014
Journal Article, peer-reviewed

Elucidating the response of Kluyveromyces lactis to arsenite and peroxide stress and the role of the transcription factor KlYap8.
Jenny Veide Vilg, Nallani Vijay Kumar, Ewa Maciaszczyk-Dziubinska, Ewa Sloma, Djamila Onesime et al.
Biochimica et biophysica acta, Volume 1839, Issue 11, Pages 1295-1306 2014
Journal Article, peer-reviewed

Heavy Metals and Metalloids As a Cause for Protein Misfolding and Aggregation
Markus J. Tamás, Sandeep K. Sharma, Sebastian Ibstedt, Therese Jacobson, Philipp Christen
Biomolecules, Volume 4, Issue 1, Pages 252-267 2014
Journal Article, peer-reviewed

Major publications

The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast.
Michael Thorsen, Yujun Di, Carolina Tängemo, Montserrat Morillas, Doryaneh Ahmadpour et al.
Molecular biology of the cell, Volume 17, Issue 10, Pages 4400-10 2006
Journal Article, peer-reviewed

Arsenite interferes with protein folding and triggers formation of protein aggregates in yeast.
Therese Jacobson, Clara Navarrete, Sandeep K Sharma, Theodora C Sideri, Sebastian Ibstedt et al.
Journal of cell science, Volume 125, Issue 21, Pages 5073-83 2012
Journal Article, peer-reviewed

Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8.
Nallani Vijay Kumar, Jianbo Yang, Jitesh K Pillai, Swati Rawat, Carlos Solano et al.
Molecular and cellular biology, Volume 36, Issue 6, Pages 913-22 2015
Journal Article, peer-reviewed

Showing 1 - 10 of 70

2016

Distinct stress conditions result in aggregation of proteins with similar properties.
Alan J Weids, Sebastian Ibstedt, Markus J. Tamás, Chris M Grant
Scientific reports, Volume 6, Pages 24554 2016
Journal Article, peer-reviewed

2015

Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8.
Nallani Vijay Kumar, Jianbo Yang, Jitesh K Pillai, Swati Rawat, Carlos Solano et al.
Molecular and cellular biology, Volume 36, Issue 6, Pages 913-22 2015
Journal Article, peer-reviewed

HwHog1 kinase activity is crucial for survival of Hortaea werneckii in extremely hyperosmolar environments.
Anja Kejžar, Morten Grøtli, Markus J. Tamás, Ana Plemenitaš, Metka Lenassi
Fungal genetics and biology : FG & B, Volume 74, Pages 45-58 2015
Journal Article, peer-reviewed

2014

Application of a peptide-based assay to characterize inhibitors targeting protein kinases from yeast
Jenny Veide Vilg, S. Dahal, T. Ljungdahl, Morten Grøtli, Markus J. Tamás
Current Genetics, Volume 60, Issue 3, Pages 193-200 2014
Journal Article, peer-reviewed

Mathematical modelling of arsenic transport, distribution and detoxification processes in yeast.
Soheil Rastgou Talemi, Therese Jacobson, Vijay Garla, Clara Navarrete, Annemarie Wagner et al.
Molecular Microbiology, Volume 92, Issue 6, Pages 1343-56 2014
Journal Article, peer-reviewed

Global analysis of protein aggregation in yeast during physiological conditions and arsenite stress.
Sebastian Ibstedt, Theodora C Sideri, Chris M Grant, Markus J. Tamás
Biology open, Volume 3, Issue 10, Pages 913-923 2014
Journal Article, peer-reviewed

Elucidating the response of Kluyveromyces lactis to arsenite and peroxide stress and the role of the transcription factor KlYap8.
Jenny Veide Vilg, Nallani Vijay Kumar, Ewa Maciaszczyk-Dziubinska, Ewa Sloma, Djamila Onesime et al.
Biochimica et biophysica acta, Volume 1839, Issue 11, Pages 1295-1306 2014
Journal Article, peer-reviewed

Heavy Metals and Metalloids As a Cause for Protein Misfolding and Aggregation
Markus J. Tamás, Sandeep K. Sharma, Sebastian Ibstedt, Therese Jacobson, Philipp Christen
Biomolecules, Volume 4, Issue 1, Pages 252-267 2014
Journal Article, peer-reviewed

2013

Showing 1 - 10 of 70

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