Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Beidong Liu

Forskare

Beidong Liu
Forskare
Akademisk grad: Docent,
lui.beidong@cmb.gu.se
031-786 2566

Rumsnummer: 1340
Postadress: Box 462, 40530 Göteborg
Besöksadress: Medicinaregatan 9C , 41390 Göteborg


Institutionen för kemi och molekylärbiologi (Mer information)
Box 462
40530 Göteborg
www.cmb.gu.se
inst.kmb@cmb.gu.se
Fax: 031-786 2599

Besöksadress: Medicinaregatan 9 c , 40530 Göteborg

Om Beidong Liu

Current position

Research

My present research interest is focused on deciphering mechanisms underlying aging-related diseases by developing and applying novel high-content screening techniques using yeast
 (Saccharomyces cerevisiae) as a model system. The powerful high throughput screening approach, developed in my group, enables me to study all the possible combinations between a phenotypic reporter of choice and a collection of gene mutants throughout the yeast genome in a few months (while a conventional manual test would take more than several decades). This approach makes it possible to pull out almost all components being part of any specific biological machinery and allows for an unbiased, genome-wide, identification of components and networks involved in, for example, protein quality control, protein aggregate formation and inheritance and epigenetic silencing.

Main ongoing research projects

  • 1. 2016-2019, Swedish Research Council (VR 2015-04984), Mechanisms controlling sequestration and detoxification of Huntingtin proteins in yeast (Saccharomyces cerevisiae).
  • 2. 2016-2017, Swedish Cancer Fund /Cancerfonden (CAN 2015/406), Identifying machineries and pathways controlling stress granule formation – roles in cancer initiation and progression.
  • 3. 2015-2016, Carl Trygger Foundation (CTS 14: 295), Deciphering machineries underlying protein inclusion body formation in yeast (Saccharomyces cerevisiae).
  • 4. MoRE (Marie Curie) fellow, 2015-2017, Marie Curie/Cofund Mobility for Regional Excellence (MoRE) fellowship. a mobility programme co-financed by the EU within the framework of the Fp7-People-COFUND programme.

Previous main research projects

  • 1. Deciphering machineries underlying thermal and disease protein induced inclusion body formation, 2012-2015, Swedish Research Council (VR 2011-5923)
  • 2. Global analysis of network control of epigenetic gene silencing regulation – potential role in age-related cancers, 2013-2015, Cancerfonden (CAN 2012/601)
  • 3. Deciphering human disease protein synphilin-1 induced inclusion body formation machineries in Saccharomyces cerevisiae, 2012-2014, Stiftelsen Olle Engkvist Byggmästare

Group members

Postdocs:

  • Xiuling Cao(main-supervisor), from 2015-08-03
  • Roja Babazadeh(co-superviser), from 2014-11-01
  • Lihua Chen(main-supervisor), from 2013-10-29
  • Doryaneh Ahmadpour (co-supervisor), from 2015-03-01

Ph.D. students:

  • Sansan Hua, from 2015-03-09 (main-supervisor)
  • Zheng Ju, from 2014-04-15 (main-supervisor)
  • Sandra Malmgren Hill, from 2012 (co-supervisor)

Permanent technician:

  • Xinxin Hao (Research assistant)

Permanent Staff of the Center for Large-scale cell-based screening:

  • Peter Dahl (Research engineer), Xinxin Hao (Research assistant)

Past lab members

  • Previous postdocs: Qian Liu (main-supervisor), from 2013-08-23 to 2015-08-23; Junsheng Yang (co-superviser), from 2011-09-01 to 2015-01-14
  • Zhao Lie, Ph.D. student; Song Jia, Ph.D.; Yang Xiaoxue, Ph.D.
  • Tom Lebacq, M.Sc.;Daniel Wiberg, M.Sc.;Eman Abbas, M.Sc.;Anna Barcons Simon, M.Sc.; Anna Sigurdsson, M.Sc.; Friederike Ewald, M.Sc.; Kathi Roempler, M.Sc.Daniel Höglund, M.Sc….

Teaching

Graduate level

  • Yeast genome-wide analysis and high content microscopy principles and basic skills, course developer and course leader.
  • Phenomics - from genotype to phenotype, main teacher.

Undergraduate level

  • Cell and Molecular Biology, 15hp (BIO213) , main teacher
  • Eukaryote molecular microbiology, 15hp (BIO440).
  • Bioinformatics and functional genomics (BIOFUN), 15hp (BIO210), main teacher.
  • Advanced Functional Genomics, 15hp (BIO406), main teacher.

 

Publikationsämnen

Senaste publikationer

Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases
Lihua Chen, Beidong Liu
Oxidative Medicine and Cellular Longevity, Forskningsöversiktsartikel 2017
Forskningsöversiktsartikel

Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions
Sandra Malmgren Hill, Xinxin Hao, Johan Grönvall, Stephanie Spikings-Nordby, Per O Widlund et al.
Cell Reports, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins
Sara Hanzén, Katarina Vielfort, Junsheng Yang, Frederike Roger, Veronica Andersson et al.
Cell, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Mediator tail subunits can form amyloid-like aggregates in vivo and affect stress response in yeast
Xuefeng Zhu, Lihua Chen, Jonas O P Carlsten, Qian Liu, Junsheng Yang et al.
Nucleic Acids Research, Artikel i vetenskaplig tidskrift 2015
Artikel i vetenskaplig tidskrift

Essential Genetic Interactors of SIR2 Required for Spatial Sequestration and Asymmetrical Inheritance of Protein Aggregates
J. Song, Q. Yang, Junsheng Yang, Lisa C Larsson, Xinxin Hao et al.
PLoS Genetics, Artikel i vetenskaplig tidskrift 2014
Artikel i vetenskaplig tidskrift

The Yin and Yang of a metacaspase
Beidong Liu
Cell Cycle, Forskningsöversiktsartikel 2014
Forskningsöversiktsartikel

Stress granule-defective mutants deregulate stress responsive transcripts
Xiaoxue Yang, Yi Shen, Elena Garré, Xinxin Hao, Daniel Krumlinde et al.
PLoS Genetics, Artikel i vetenskaplig tidskrift 2014
Artikel i vetenskaplig tidskrift

Life-span extension by a metacaspase in the yeast Saccharomyces cerevisiae
Sandra Malmgren Hill, Xinxin Hao, Beidong Liu, Thomas Nyström
Science, Artikel i vetenskaplig tidskrift 2014
Artikel i vetenskaplig tidskrift

The mystery of aging and rejuvenation - a budding topic
Thomas Nyström, Beidong Liu
Current Opinion in Microbiology, Forskningsöversiktsartikel 2014
Forskningsöversiktsartikel

Visar 1 - 10 av 21

2017

Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases
Lihua Chen, Beidong Liu
Oxidative Medicine and Cellular Longevity, Forskningsöversiktsartikel 2017
Forskningsöversiktsartikel

2016

Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions
Sandra Malmgren Hill, Xinxin Hao, Johan Grönvall, Stephanie Spikings-Nordby, Per O Widlund et al.
Cell Reports, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins
Sara Hanzén, Katarina Vielfort, Junsheng Yang, Frederike Roger, Veronica Andersson et al.
Cell, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

2015

Mediator tail subunits can form amyloid-like aggregates in vivo and affect stress response in yeast
Xuefeng Zhu, Lihua Chen, Jonas O P Carlsten, Qian Liu, Junsheng Yang et al.
Nucleic Acids Research, Artikel i vetenskaplig tidskrift 2015
Artikel i vetenskaplig tidskrift

2014

Essential Genetic Interactors of SIR2 Required for Spatial Sequestration and Asymmetrical Inheritance of Protein Aggregates
J. Song, Q. Yang, Junsheng Yang, Lisa C Larsson, Xinxin Hao et al.
PLoS Genetics, Artikel i vetenskaplig tidskrift 2014
Artikel i vetenskaplig tidskrift

The Yin and Yang of a metacaspase
Beidong Liu
Cell Cycle, Forskningsöversiktsartikel 2014
Forskningsöversiktsartikel

Stress granule-defective mutants deregulate stress responsive transcripts
Xiaoxue Yang, Yi Shen, Elena Garré, Xinxin Hao, Daniel Krumlinde et al.
PLoS Genetics, Artikel i vetenskaplig tidskrift 2014
Artikel i vetenskaplig tidskrift

Life-span extension by a metacaspase in the yeast Saccharomyces cerevisiae
Sandra Malmgren Hill, Xinxin Hao, Beidong Liu, Thomas Nyström
Science, Artikel i vetenskaplig tidskrift 2014
Artikel i vetenskaplig tidskrift

The mystery of aging and rejuvenation - a budding topic
Thomas Nyström, Beidong Liu
Current Opinion in Microbiology, Forskningsöversiktsartikel 2014
Forskningsöversiktsartikel

Visar 1 - 10 av 21

Sidansvarig: Ann Svensson|Sidan uppdaterades: 2016-06-20
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?