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Mate Erdelyi

Universitetslektor

Mate Erdelyi
Universitetslektor
Akademisk grad: Docent,
mate.erdelyi@gu.se
031-786 9033
0766-229033

Rumsnummer: 8023
Postadress: Kemigården 4, 412 96 Göteborg
Besöksadress: Kemigården 4 , 412 96 Göteborg


Institutionen för kemi och molekylärbiologi (Mer information)
Box 462
40530 Göteborg
www.cmb.gu.se
inst.kmb@cmb.gu.se
Fax: 031-786 2599

Besöksadress: Medicinaregatan 9 c , 40530 Göteborg

Om Mate Erdelyi

RESEARCH

1. Development of metallo-beta-lactamase inhibitors to control antibiotic resistance

The appearance of superbugs producing metallo-beta-lactamases (MβLs) have resulted in a clinical crisis. In this collaborative project, subclasses of MβLs including NDM-1 are expressed and purified and a a series of beta-lactam antibiotics transition state analogs are synthesized. Their broad-spectrum inhibition activity and structure-activity relationship is evaluated. Special attention will be given to possible synergestic effects when applied in combination with antibiotics for inhibition of antibiotic resistant bacteria. The complexes of MβLs and the transition state analogs are studied by NMR and X-ray crystallography, to provide information useful for the development of clinically applicable broad spectrum inhibitors. The long term goal of this project is to create novel compounds with broad-spectrum inhibitory potency to MβLs and superbugs, and to provide a deeper understanding of molecular processes behind antibiotic action that is expected to support the development of additional antibacterial drugs.

2. Understanding Halogen Bonding in Solution

Halogen bonding is an electron density donation-based weak interaction that has so far mostly been investigated in computational and crystallographic studies.

We examine halogen bonding formed in solution environment employing a novel, exceedingly accurate NMR methodology. Using a combination of spectroscopic and computational techniques the energetics of halogen bonds and the role of electrostatic and non-electrostatic effects in the interaction will be studied. Variation of bond length and symmetry as well as their relevance in inter- and intramolecular interactions are being elucidated.

The gained knowledge will be applied to understand the impact of halogen bonding in biological systems, such as protein-ligand and lipide-ligand interactions as well as used to develop new applications of halogen bonding in organic, analytical and pharmaceutical chemistry.

3. Exploration of Antimalarial Natural Products from Kenyan Plants

Malaria, caused by the protozoan parasites of the genus Plasmodium, is a major disease in the tropical and subtropical regions of the world. Out of yearly 300 to 500 million clinical episodes, of which 90% occur in tropical sub-Saharan region, 1.5-2.7 million are lethal. Notably, malaria is the leading cause of mortality of children under five years of age and of pregnant women in this area. The emergence of chloroquine-resistant strains of the parasite Plasmodium falciparum and the rising resistance of the vectors (Anopheles spp.) to insecticides in combination with poverty and lack of a well-functioning health care system are the main causes for the increase of malaria morbidity and mortality over the past decade. To date over thousand herbal species are in use in indigenous health systems as means of treating malaria and managing related fever; however, their efficacy and active components have not yet been studied systematically. Although there are several antimalarial drugs on the market, most do not meet the requirement of ≤ 1 USD per treatment and are unaffordable for the majority of Africa. Chloroquine and sulphadoxine-pyrimethamine are the only remedy available for such low price; however, the already widespread and relentlessly increasing resistance against these agents makes them virtually useless. The discovery of Artemisinin from Artemisia annua showed that plants used in traditional medicine may provide new source of lead structures for the development of novel antiplasmodial drugs.

The goal of this ongoing project is identification of novel pharmaceutical lead compounds from the Kenyan flora by evaluation of efficacious traditional remedies by modern techniques. We collaborate with the research group of Prof. Abiy Yenesew at the University of Nairobi, Kenya, and aim to join our forces by integrating cultural practice with modern pharmaceutical approaches to advance new solutions to malaria, the disease of highest mortality in sub-Saharan Africa. Expected outcomes of the project are bioactive natural products rapidly transferable to the treatment of malaria - either through identification of new lead compounds or through development of phytomedicines.
 

TEACHING

KEM030/031 Organic chemistry (15 credits) of chemistry and pharmacy students

Small molecular NMR spectroscopy (15 credits) for Ph.D. students
 

COMMISSIONS

Board member in the Organic Chemistry section of the Swedish Chemical Society
 

QUALIFICATIONS

Halogen bonding, NMR spectroscopy, synthesis, medicinal chemistry

Utvalda publikationer

Mapping the sevoflurane-binding site of calmodulin
Ulrika Brath, Kelvin Lau, Filip Van Petegem, Mate Erdelyi
Pharmacology Research & Perspectives, 2014

Symmetric Halogen Bonding is Preferred in Solution
Anna-Carin Carlsson, Jürgen Gräfenstein, Adnan Budnjo, Jonas Bergquist, Alavi Karim et al.
Journal of the American Chemical Society, 2012

Senaste publikationer

Photochemically Induced Aryl Azide Rearrangement: Solution NMR Spectroscopic Identification of the Rearrangement Product
Hanna Andersson, Jürgen Gräfenstein, Minoru Isobe, Mate Erdelyi, Magne O. Sydnes
Journal of Organic Chemistry, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Polyoxygenated Cyclohexenes and Other Constituents of Cleistochlamys kirkii Leaves
Stephen S. Nyandoro, Joan Munissi, Amra Gruhonjic, Sandra Duffy, Fangfang Pan et al.
Journal of natural products, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Pterocarpans and isoflavones from the roots of Millettia micans and of Millettia dura
Marco Makungu, Tsegaye Deyou, Amra Gruhonjic, John P. Holleran, Sandra Duffy et al.
Advances in Drug Discovery and Development, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic β-hairpins
Emma Danelius, Mariell Pettersson, Matilda Bred, Jaeki Min, M. Brett Waddell et al.
Organic and Biomolecular Chemistry, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis
Per Aronsson, Joan J. E. Munissi, Amra Gruhonjic, Paul A. Fitzpatrick, Göran Landberg et al.
Diseases, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei
Negera Abdissa, F. Pan, Amra Gruhonjic, Jürgen Gräfenstein, Paul A. Fitzpatrick et al.
Journal of natural products, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Substituent Effects on the [N–I–N]+ Halogen Bond
Anna-Carin Carlsson, Krenare Mehmeti, Martin Uhrbom, Alavi Karim, Michele Bedin et al.
Journal of the American Chemical Society, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Efficient Isotope Editing of Proteins for Site-Directed Vibrational Spectroscopy
Sebastian Peuker, Hanna Andersson, Emil Gustavsson, K. S. Maiti, R Kania et al.
Journal of the American Chemical Society, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Rotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis
Tsegaye Deyou, Ivan Gumula, F. F. Pang, Amra Gruhonjic, M. Mumo et al.
Journal of Natural Products, Artikel i vetenskaplig tidskrift 2015
Artikel i vetenskaplig tidskrift

The Impact of Interchain Hydrogen Bonding on b-Hairpin Stability is Readily Predicted by Molecular Dynamics Simulation
Stephan Niebling, Emma Danelius, Ulrika Brath, Sebastian Westenhoff, Mate Erdelyi
Peptide Science, Artikel i vetenskaplig tidskrift 2015
Artikel i vetenskaplig tidskrift

Utvalda publikationer

Mapping the sevoflurane-binding site of calmodulin
Ulrika Brath, Kelvin Lau, Filip Van Petegem, Mate Erdelyi
Pharmacology Research & Perspectives, 2014

Symmetric Halogen Bonding is Preferred in Solution
Anna-Carin Carlsson, Jürgen Gräfenstein, Adnan Budnjo, Jonas Bergquist, Alavi Karim et al.
Journal of the American Chemical Society, 2012

Visar 1 - 10 av 57

2017

Photochemically Induced Aryl Azide Rearrangement: Solution NMR Spectroscopic Identification of the Rearrangement Product
Hanna Andersson, Jürgen Gräfenstein, Minoru Isobe, Mate Erdelyi, Magne O. Sydnes
Journal of Organic Chemistry, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Polyoxygenated Cyclohexenes and Other Constituents of Cleistochlamys kirkii Leaves
Stephen S. Nyandoro, Joan Munissi, Amra Gruhonjic, Sandra Duffy, Fangfang Pan et al.
Journal of natural products, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

2016

Pterocarpans and isoflavones from the roots of Millettia micans and of Millettia dura
Marco Makungu, Tsegaye Deyou, Amra Gruhonjic, John P. Holleran, Sandra Duffy et al.
Advances in Drug Discovery and Development, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic β-hairpins
Emma Danelius, Mariell Pettersson, Matilda Bred, Jaeki Min, M. Brett Waddell et al.
Organic and Biomolecular Chemistry, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis
Per Aronsson, Joan J. E. Munissi, Amra Gruhonjic, Paul A. Fitzpatrick, Göran Landberg et al.
Diseases, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei
Negera Abdissa, F. Pan, Amra Gruhonjic, Jürgen Gräfenstein, Paul A. Fitzpatrick et al.
Journal of natural products, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Substituent Effects on the [N–I–N]+ Halogen Bond
Anna-Carin Carlsson, Krenare Mehmeti, Martin Uhrbom, Alavi Karim, Michele Bedin et al.
Journal of the American Chemical Society, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Efficient Isotope Editing of Proteins for Site-Directed Vibrational Spectroscopy
Sebastian Peuker, Hanna Andersson, Emil Gustavsson, K. S. Maiti, R Kania et al.
Journal of the American Chemical Society, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

2015

Rotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis
Tsegaye Deyou, Ivan Gumula, F. F. Pang, Amra Gruhonjic, M. Mumo et al.
Journal of Natural Products, Artikel i vetenskaplig tidskrift 2015
Artikel i vetenskaplig tidskrift

The Impact of Interchain Hydrogen Bonding on b-Hairpin Stability is Readily Predicted by Molecular Dynamics Simulation
Stephan Niebling, Emma Danelius, Ulrika Brath, Sebastian Westenhoff, Mate Erdelyi
Peptide Science, Artikel i vetenskaplig tidskrift 2015
Artikel i vetenskaplig tidskrift

Visar 1 - 10 av 57

Sidansvarig: Ann Svensson|Sidan uppdaterades: 2016-06-20
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