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Morten Grötli

Professor

Morten Grötli
Professor
Akademisk grad: Docent,
morten.grotli@gu.se
031-786 9017
0766-229017

Rumsnummer: 8013
Postadress: Kemigården 4, 412 96 Göteborg
Besöksadress: Kemigården 4 , 412 96 Göteborg


Institutionen för kemi och molekylärbiologi (Mer information)
Box 462
405 30 Göteborg
www.cmb.gu.se
inst.kmb@cmb.gu.se
Fax: 031-786 2599

Besöksadress: Medicinaregatan 9 C , 405 30 Göteborg

Om Morten Grötli

The focus of the Grøtli lab is the use of synthetic organic chemistry to produce novel compounds for the study of problems important in cell biology and medicine. Such compounds are interesting both as potential therapeutics and as experimental tools for understanding the physiological roles of the target proteins. Two types of compounds are of special interest: probes for visualization (e.g. fluorescence-based sensors for detection of enzymatic activity in vivo and in vitro; fluorescent-nucleic acid base analogues), and probes for selective perturbation of biological processes (e.g. kinase inhibitors).

Utvalda publikationer

Design, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors.
Rubén Ferreira, Jesper Nilsson, Carlos Solano, Joakim Andréasson, Morten Grøtli
Scientific reports, 2015

Development of bright fluorescent quadracyclic adenine analogues: TDDFT-calculation supported rational design
Anders Foller Larsen, Blaise Dumat, Moa Sandberg Wranne, Christopher P. Lawson, S. Preus et al.
Scientific Reports, 2015

Senaste publikationer

Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET
M. S. Wranne, A. F. Fuchtbauer, B. Dumat, Mattias Bood, A. H. El-Sagheer et al.
Journal of the American Chemical Society, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Network analyses identify liver-specific targets for treating liver diseases.
Sunjae Lee, Cheng Zhang, Zhengtao Liu, Martina Klevstig, Bani Mukhopadhyay et al.
Molecular systems biology, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

On the use of diarylmaleimide derivatives in biological contexts: An investigation of the photochromic properties in aqueous solution
C. Fleming, P. Remon, S. Li, N. A. Simeth, B. Konig et al.
Dyes and Pigments, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic β-hairpins
Emma Danelius, Mariell Pettersson, Matilda Bred, Jaeki Min, M. Brett Waddell et al.
Organic and Biomolecular Chemistry, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases
M. I. Valencia-Sanchez, A. Rodriguez-Hernandez, Rubén Ferreira, H. A. Santamaria-Suarez, M. Arciniega et al.
Journal of Biological Chemistry, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein
M. Tokugawa, Y. Masaki, J. C. Canggadibrata, K. Kaneko, T. Shiozawa et al.
Chemical Communications, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

An acido- and photochromic molecular device that mimics triode action
P. Remón, Shiming Li, Morten Grötli, U. Pischel, Joakim Andréasson
Chemical Communications, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Defects in the calcium-binding region drastically affect the cadherin-like domains of RET tyrosine kinase
Chunxia Gao, Morten Grøtli, Leif A Eriksson
Physical Chemistry Chemical Physics, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Chroman-4-one and chromone based somatostatin beta-turn mimetics
Maria Fridén-Saxin, Tina Seifert, Marcus Malo, Krystle da Silva Andersson, Nils Pemberton et al.
European Journal of Medicinal Chemistry, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Second-Generation Fluorescent Quadracyclic Adenine Analogues: Environment-Responsive Probes with Enhanced Brightness
B. Dumat, Mattias Bood, Moa Sandberg Wranne, Christopher P. Lawson, Anders Foller Larsen et al.
Chemistry - A European Journal, Artikel i vetenskaplig tidskrift 2015
Artikel i vetenskaplig tidskrift

Utvalda publikationer

Design, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors.
Rubén Ferreira, Jesper Nilsson, Carlos Solano, Joakim Andréasson, Morten Grøtli
Scientific reports, 2015

Development of bright fluorescent quadracyclic adenine analogues: TDDFT-calculation supported rational design
Anders Foller Larsen, Blaise Dumat, Moa Sandberg Wranne, Christopher P. Lawson, S. Preus et al.
Scientific Reports, 2015

Visar 1 - 10 av 76

2017

Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET
M. S. Wranne, A. F. Fuchtbauer, B. Dumat, Mattias Bood, A. H. El-Sagheer et al.
Journal of the American Chemical Society, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Network analyses identify liver-specific targets for treating liver diseases.
Sunjae Lee, Cheng Zhang, Zhengtao Liu, Martina Klevstig, Bani Mukhopadhyay et al.
Molecular systems biology, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

On the use of diarylmaleimide derivatives in biological contexts: An investigation of the photochromic properties in aqueous solution
C. Fleming, P. Remon, S. Li, N. A. Simeth, B. Konig et al.
Dyes and Pigments, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

2016

Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic β-hairpins
Emma Danelius, Mariell Pettersson, Matilda Bred, Jaeki Min, M. Brett Waddell et al.
Organic and Biomolecular Chemistry, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases
M. I. Valencia-Sanchez, A. Rodriguez-Hernandez, Rubén Ferreira, H. A. Santamaria-Suarez, M. Arciniega et al.
Journal of Biological Chemistry, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein
M. Tokugawa, Y. Masaki, J. C. Canggadibrata, K. Kaneko, T. Shiozawa et al.
Chemical Communications, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

An acido- and photochromic molecular device that mimics triode action
P. Remón, Shiming Li, Morten Grötli, U. Pischel, Joakim Andréasson
Chemical Communications, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Defects in the calcium-binding region drastically affect the cadherin-like domains of RET tyrosine kinase
Chunxia Gao, Morten Grøtli, Leif A Eriksson
Physical Chemistry Chemical Physics, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

Chroman-4-one and chromone based somatostatin beta-turn mimetics
Maria Fridén-Saxin, Tina Seifert, Marcus Malo, Krystle da Silva Andersson, Nils Pemberton et al.
European Journal of Medicinal Chemistry, Artikel i vetenskaplig tidskrift 2016
Artikel i vetenskaplig tidskrift

2015

Second-Generation Fluorescent Quadracyclic Adenine Analogues: Environment-Responsive Probes with Enhanced Brightness
B. Dumat, Mattias Bood, Moa Sandberg Wranne, Christopher P. Lawson, Anders Foller Larsen et al.
Chemistry - A European Journal, Artikel i vetenskaplig tidskrift 2015
Artikel i vetenskaplig tidskrift

Visar 1 - 10 av 76

Sidansvarig: Katleen Burm|Sidan uppdaterades: 2016-06-20
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