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Regulation of Mitochondrial Apoptosis: Molecular Mechanisms of the Bcl-2 Proteins


Removal of cells via programmed cell death (apoptosis) is an essential mechanism in life. Upon internal stress clearance of undesired cells is executed via intrinsic (mitochondrial) apoptosis, a pathway tightly controlled by the Bcl-2 protein family. Its pro- and anti-apoptotic members meet at the mitochondrial surface, more precisely at its outer membrane system, where they arbitrate a life or death (membrane permeabilization) decision. Failures cause pathological disorders including abnormal embryogenic development and cancer. However, how opposing Bcl-2 members meet and form a sophisticated regulative network there, is still poorly understood due to the lack of structural and functional information for these proteins acting at the the mitochondrial membraneous surface.

To provide structural about this molecular regulation mechanism occurring at the mitochondrial outer membrane system, we apply solid-state/liquid NMR approaches together with neutron reflectometry on two representative Bcl-2 family members, namely the anti-apoptotic Bcl-2 protein itself which is an integral membrane protein, and its counterpart, the pro-apoptotic, membrane perforating Bax protein.

Föreläsare: Gerhard Gröbner (https://www.umu.se/en/staff/gerhard-grobner/)

Datum: 2019-11-14

Tid: 12:00 - 13:00

Kategorier: Naturvetenskap

Plats: Sal KC, Kemihuset, Campus Johanneberg

Kontaktperson: Pernilla Wittung-Stafshede

Sidansvarig: |Sidan uppdaterades: 2012-01-02

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