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Postdoctoral scholarship: Nanoanalytical Methods to Chemically Dissect Neurotransmitter Vesicles

Nyhet: 2018-04-13

The Department of Chemistry and Molecular Biology, University of Gothenburg, offers a postdoctoral scholarship in Nanoanalytical Methods to Chemically Dissect Neurotransmitter Vesicles.

The scholarship holder will work on a project to develop new electrochemical and mass spectrometry approaches to analyze nanometer vesicles in model nerve-like cells and nerve cells in the fruit fly model, Drosophila. A part of this work will be to investigate other transmitters, like adenosine. Overall, this work will be aimed at 1) allowing us to quantify vesicle content both in situ and in live nerve cells, and 2) providing a mechanism for changes in synaptic strength. This mechanism could affect everything from learning and memory to neurodegeneration. Another goal is will be to develop and use nanoscale mass spectrometry imaging to examine the parameters that regulate exchange of neurotransmitter between the vesicular dense core and the halo, studied with pharmacological tools. This will provide a mechanism for changes in synaptic strength when cells communicate and provide a new paradigm for the development of drugs. A goal will be to investigate the impact on neurotransmission from the discovery, made by us, that only a fraction of the transmitter molecules are released during a typical exocytosis full fusion event.

Dnr E 2018/264

Scholarship period: The scholarship covers a period of 24 months in total.

Preliminary start date: 2018-09-01

Supervisor/contact person: Andrew Ewing, +46 (0)761172293, andrewe@chem.gu.se

Qualifications:

* To be eligible for a post-doc scholarship at the recipient must hold a PhD degree within a relevant field. The applicant must not have been employed at University of Gothenburg in the past two years.

* Applications for this scholarship must have experience with research focusing on detection of rapid changes in adenosine and oxygen release in vivo using fast-scan cyclic voltammetry at carbon-fiber microelectrodes in rat and mouse models, development of novel microelectrodes including carbon nanotube yarns, development of carbon nanotube-polyimide composites to make high temperature flexible thin film strain sensors.

Written application, including reference number, is to be sent via e-mail to the supervisor and must include the following:

* CV

* Personal letter stating the reasons why the study suits the applicant (maximum one page)

* List of publications

* References (2)

Application deadline: 2018-05-06

Information regarding scholarships:

* Scholarships do not give rise to sickness benefits, compensation from the Social Insurance Office or retirement pension.

* The scholarship sum is paid out quarterly

* Scholarships are tax-exempt

* A scholarship holder cannot be hired after the scholarship period due to tax reasons.

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