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Gisela Brändén

Senior lecturer

Gisela Brändén
Senior lecturer
+46 31 786 3915

Room number: 1212
Postal Address: Box 462, 40530 Göteborg
Visiting Address: Medicinaregatan 9C , 41390 Göteborg

Department of Chemistry & Molecular Biology (More Information)
Box 462
405 30 Göteborg
Fax: +46 31 786 2599
Visiting Address: Medicinaregatan 9 C , 413 90 Göteborg

About Gisela Brändén

I am a structural biologist/biochemist with experience from pharmaceutical industry. I am leading a research group at the Department of Chemistry and Molecular Biology at the University of Gothenburg.

The focus of my research group is to study the structure, function and dynamics of membrane proteins. We use a combination of different biochemical and biophysical methods to describe proteins in detail as they work, including X-ray crystallography, absorbance spectroscopy, X-ray Scattering and X-ray Free Electron Laser (XFEL) coherent diffractive imaging. We put a lot of effort into development of time resolved synchrotron- and XFEL-based methods, including serial crystallography. Using these methods we investigate the energy converting systems of the cell, more specifically cytochrome oxidase of the respiratory chain and bacterial photosynthetic reaction center. In addition we use microtubules, the major constituent of the cytoskeleton, as a model system for XFEL imaging. I collaborate closely with MAX IV Laboratories on advancing synchrotron-based serial crystallography, and together with AstraZeneca we are interested in exploring the use of serial crystallography applied to pharmaceutical targets.

My other area of focus is structure-based drug design. In collaboration with AstraZeneca we study the membrane-bound protein MraY, essential for bacterial cell wall synthesis. As such, MraY is a very interesting target to overcome the acutely developing problem of antibiotic resistance. We describe how MraY interacts with different inhibitors, with the long-term goal to develop novel antibiotic compounds. I also have experience in structural studies of the cytochrome P450s, the main drug-metabolizing system in the body.

Link to Google scholar: https://scholar.google.se/citations?user=A9uO-GIAAAAJ&hl=eng

I am course responsible for our second year biochemistry course KEM060 (15 hec) where I lecture on cell metabolism. In addition, I lecture on structure-based drug design on two of our advanced courses, KEM360 and BIO523.

I am responsible for Outreach at the department (see https://cmb.gu.se/samverkan) and member of the Committee for Collaboration, Innovation and Internationalisation for the Faculty of Science. I am also member of the Docent Board for the faculty.

Group members:
Cecilia Safari, PhD student
Jenny Hering, PhD student
Andreas Dunge, PhD student
Swagatha Ghosh, postdoc
Owens Uwangue, PhD student
Doris Zoric, PhD student

PhD students to have graduated:
Elin Dunevall (2019) ”Structural and Functional Studies of Membrane Proteins – For Future Development of Antimicrobial Drugs”

Swedish Research Council, Swedish Foundation for Strategic Research, Carl Trygger Foundation

Latest publications

A simple adaptation to a protein crystallography station to facilitate difference X-ray scattering studies
Amit Sharma, Peter Berntsen, Rajiv Harimoorthy, R. Appio, Jennie Sjöhamn et al.
Journal of Applied Crystallography, Journal article 2019
Journal article

Flow-aligned, single-shot fiber diffraction using a femtosecond X-ray free-electron laser.
David Popp, N Duane Loh, Habiba Zorgati, Umesh Ghoshdastider, Lu Ting Liow et al.
Cytoskeleton (Hoboken, N.J.), Journal article 2017
Journal article

MraY-antibiotic complex reveals details of tunicamycin mode of action.
Jonna K Hakulinen, Jenny Hering, Gisela Brändén, Hongming Chen, Arjan Snijder et al.
Nature chemical biology, Journal article 2017
Journal article

Membrane protein structural biology using X-ray free electron lasers
Richard Neutze, Gisela Brändén, G.F.X. Schertler
Current Opinion in Structural Biology, Journal article 2015
Journal article

Structure-based ligand design to overcome CYP inhibition in drug discovery projects
Gisela Brändén, T. Sjogren, V. Schnecke, Y. F. Xue
Drug Discovery Today, Review article 2014
Review article

Showing 11 - 20 of 21


Deuterium isotope effect of proton pumping in cytochrome c oxidase
Lina Salomonsson, Gisela Brändén, Peter Brzezinski
Biochimica et Biophysica Acta, Journal article 2008
Journal article

Structural elements involved in proton translocation by cytochrome c oxidase as revealed by backbone amide hydrogen-deuterium exchange of the E286H mutant
Laura Busenlehner, Gisela Brändén, Ida Namslauer, Peter Brzezinski, Richard Armstrong
Biochemistry, Journal article 2008
Journal article


Controlled uncoupling and re-coupling of proton pumping in cytochrome c oxidase
Gisela Brändén, Ashtamurthy Pawate, Robert Gennis, Peter Brzezinski
Proceedings of the National Academy of Science of the United States of America, Journal article 2006
Journal article

Transmembrane proton translocation by cytochrome c oxidase
Gisela Brändén, Robert Gennis, Peter Brzezinski
Biochimica et Biophysica Acta, Journal article 2006
Journal article


The protonation state of a heme propionate controls electron transfer in cytochrome c oxidase
Gisela Brändén, Magnus Brändén, Bryan Schmidt, Denise Mills, Shelagh Ferguson-Miller et al.
Biochemistry, Journal article 2005
Journal article


Deformation of helix C in the low-temperature L-intermediate of Bacteriorhodopsin
Karl Edman, Antoine Royant, Gisela Larsson, Frida Jacobson, Tom Taylor et al.
Journal of Biological Chemistry, Journal article 2004
Journal article


Redox-driven proton pumping by heme-copper oxidases
Gisela Brändén, Peter Brzezinski
Biochimica et Biophysica Acta, Review article 2003
Review article


The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroides
Margareta Svensson-Ek, Jeff Abramson, Gisela Larsson, Susanna Törnroth, Peter Brzezinski et al.
Journal of Molecular Biology, Journal article 2002
Journal article

Protein crystallography in a vapour stream: data collection, reaction initiation and intermediate trapping in naked hydrated protein crystals
Tove Sjögren, Gunilla Carlsson, Gisela Larsson, Andras Hajdu, Christer Andersson et al.
Journal of Applied Crystallography, Journal article 2002
Journal article


The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site
Jeff Abramson, Sirpa Riistama, Gisela Larsson, Audrius Jasaitis, Margareta Svensson-Ek et al.
Nature Structural Biology, Journal article 2000
Journal article

Showing 11 - 20 of 21

Page Manager: Katleen Burm|Last update: 9/20/2013

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