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Hiroki Shibuya


Hiroki Shibuya

Postal Address: Box 462, 40530 Göteborg
Visiting Address: Medicinaregatan 9 c , 41390 Göteborg

Department of Chemistry & Molecular Biology (More Information)
Box 462
405 30 Göteborg
Fax: +46 31 786 2599
Visiting Address: Medicinaregatan 9 C , 413 90 Göteborg

About Hiroki Shibuya

Meiosis is a specialized form of cell division for producing haploid germ cells. Errors in meiosis lead to chromosomal aneuploidy, the leading cause of miscarriage and developmental and intellectual disabilities. The critical event during meiosis is the pairing and recombination of homologous chromosomes, which occurs during meiotic prophase I.
The pairing and recombination of homologous chromosomes increases genetic diversity, promotes evolution, and, more crucially, ensures the correct segregation of homologous chromosomes during the following cell divisions. 

Our studies try to address the fundamental question of how pairing and recombination of homologous chromosomes are regulated on the molecular level during mammalian meiosis using the mouse as our model system. We employ a combination of genetic, molecular, cytological, and biochemical approaches. Specifically, we are pursuing the following major projects:

1: Dissection of telomere functions required for homologous pairing.
2: Screening for novel proteins regulating meiotic recombination.

We are actively looking for postdoctoral researchers and PhD students. If you are interested in our group, please inquire by contacting Hiroki directly by email (hiroki.shibuya@gu.se).

Lab Homepage

Latest publications

The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline.
Simon Yuan Wang, Hui Mao, Hiroki Shibuya, Satoru Uzawa, Zach Klapholz O'Brown et al.
PLoS genetics, Journal article 2019
Journal article

Sources of artifact in measurements of 6mA and 4mC abundance in eukaryotic genomic DNA.
Zach K O'Brown, Konstantinos Boulias, Jie Wang, Simon Yuan Wang, Natasha M O'Brown et al.
BMC genomics, Journal article 2019
Journal article

Live-cell microscopy of meiosis in spermatocytes.
Hiroki Shibuya, Yoshinori Watanabe
Methods in cell biology, Journal article 2018
Journal article

Dissecting the telomere-inner nuclear membrane interface formed in meiosis.
Devon F Pendlebury, Yasuhiro Fujiwara, Valerie M Tesmer, Eric M Smith, Hiroki Shibuya et al.
Nature structural & molecular biology, Journal article 2017
Journal article

Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice
Marcello Stanzione, Marek Baumann, Frantzeskos Papanikos, Ihsan Dereli, Julian Lange et al.
Nature Cell Biology, Journal article 2016
Journal article

Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope
Petra Mikolcevic, Michitaka Isoda, Hiroki Shibuya, Ivan del Barco Barrantes, Ana Igea et al.
Nature communications, Journal article 2016
Journal article

MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap
Hiroki Shibuya, Abrahan Hernández-Hernández, Akihiro Morimoto, Lumi Negishi, Christer Höög et al.
Cell, Journal article 2015
Journal article

Showing 11 - 16 of 16


The meiosis specific modification of mammalian telomeres
Hiroki Shibuya, Yoshinori Watanabe
Cell Cycle, Review article 2014
Review article

Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes.
Kei-Ichiro Ishiguro, Jihye Kim, Hiroki Shibuya, Abrahan Hernández-Hernández, Aussie Suzuki et al.
Genes & development, Journal article 2014
Journal article

The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis.
Hiroki Shibuya, Kei-ichiro Ishiguro, Yoshinori Watanabe
Nature cell biology, Journal article 2014
Journal article

Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein
Katrin Daniel, Daniel Tränkner, Lukasz Wojtasz, Hiroki Shibuya, Yoshinori Watanabe et al.
BMC Cell Biology, Journal article 2014
Journal article


A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis
Akihiro Morimoto, Hiroki Shibuya, Xiaoqiang Zhu, Jihye Kim, Kei Ichiro Ishiguro et al.
Journal of Cell Biology, Journal article 2012
Journal article

Showing 11 - 16 of 16

Page Manager: Katleen Burm|Last update: 9/20/2013

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