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Markus Tamas


Markus Tamas
Professor , Head of Department
molecular biology/genetics/biochemistry/yeast
+46 31 786 2548

Room number: 1450
Postal Address: Box 462, 40530 Göteborg
Visiting Address: Medicinaregatan 9 c , 41390 Göteborg

Department of Chemistry & Molecular Biology (More Information)
Box 462
405 30 Göteborg
Fax: +46 31 786 2599
Visiting Address: Medicinaregatan 9 C , 413 90 Göteborg

About Markus Tamas

Contact details: Lundberg Laboratory, Medicinaregatan 9, Room number 1415



Molecular biology of metal toxicity and tolerance

Many metals endanger the environment and human health, but are also increasingly used as therapeutic agents for medical treatment. Yet, little is known about the molecular mechanisms causing metal toxicity or the mechanisms by which eukaryotic cells counteract toxicity and acquire tolerance.
To gain insights into metal action and cellular tolerance mechanisms, we use front-line tools in molecular biology, biochemistry, cell biology, chemical biology and functional genomics. We study (1) transport proteins through which metals enter or leave cells, (2) signal transduction and transcriptional regulatory mechanisms that cells use to sense and respond to metals, and (3) proteins and cellular processes that are targeted by metals. We use the model eukaryote Saccharomyces cerevisiae to explore fundamental aspects of metal biology and also as a heterologous expression system to study tolerance factors from other organisms such as plants and mammals.

Publications ResearcherID: www.researcherid.com/rid/E-8183-2010

Publications Google Scholar: scholar.google.se/citations

Research team: Stefanie Andersson (PhD student), Joana Rodrigues (PhD student), Sansan Hua (PhD student), Emma Lorentzon (PhD student), Antonia Romero (postdoc)


  • Eukaryotic Molecular Microbiology (BIO440)
  • Molecular Microbiology (BIO277)
  • Cell biology (BIO900)



  • Head of Department: Department of Chemistry and Molecular Biology



Markus J. Tamás studied molecular biology and biochemistry in Lund (Sweden) and Liège (Belgium) and spent a year as a research scholar at the Public Health Research Institute in New York (USA). Markus completed his PhD at the Katholieke Universiteit Leuven (Belgium) in 1999 and then moved to Gothenburg. Markus was awarded an assistant professorship by the Swedish Research Council in 2003 and became professor in eukaryotic microbiology in 2010.

Latest publications

The ancillary N-terminal region of the yeast AP-1 transcription factor Yap8 contributes to its DNA binding specificity.
Ewa Maciaszczyk-Dziubinska, Anna Reymer, Nallani Vijay Kumar, Wojciech Białek, Katarzyna Mizio et al.
Nucleic acids research, Journal article 2020
Journal article

Loss of transcriptional control affects As(III)-induced protein aggregation
Joana Rodrigues, Stefanie Andersson, Sansan Hua, Xinxin Hao, Therese Jacobson et al.
Gordon Research Conference on Stress Proteins in Growth, Development & Disease 2019, Lucca, Italy, Poster 2019

Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and toxicity
Stefanie Andersson, Joana Rodrigues, Antonia Romero, Sansan Hua, Xinxin Hao et al.
International Conference on Yeast Genetics and Molecular Biology, Gothenburg, Sweden, workshop presentation (2019), Conference contribution 2019
Conference contribution

Editorial: Molecular Mechanisms of Metalloid Transport, Toxicity and Tolerance.
Gerd Patrick Bienert, Markus J. Tamás
Frontiers in cell and developmental biology, Editorial letter 2018
Editorial letter

Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo.
Markus J. Tamás, Bruno Fauvet, Philipp Christen, Pierre Goloubinoff
Current genetics, Review article 2018
Review article

Metal and metalloids cause protein misfolding and aggregation
Stefanie Andersson, Therese Jacobson, Smriti Priya, Sandeep K. Sharma, Sofia Jakobsson et al.
International Conference on Yeast Genetics and Molecular Biology, Prague, Czech Republic, workshop presentation (2017), Conference contribution 2017
Conference contribution

Metal and metalloids cause protein misfolding and aggregation
Stefanie Andersson, Therese Jacobson, Smriti Priya, Sandeep K. Sharma, Sofia Jakobsson et al.
Gordon Research Conference on Stress Proteins in Growth, Development & Disease, Newry, USA, Poster (2017), Poster 2017

Cadmium Causes Misfolding and Aggregation of Cytosolic Proteins in Yeast.
Therese Jacobson, Smriti Priya, Sandeep K Sharma, Stefanie Andersson, Sofia Jakobsson et al.
Molecular and Cellular Biology, Journal article 2017
Journal article

The mitogen-activated protein kinase Slt2 modulates arsenite transport through the aquaglyceroporin Fps1
Doryaneh Ahmadpour, Ewa Maciaszczyk-Dziubinska, Roja Babazadeh, Sita Dahal, Magdalena Migocka et al.
FEBS Letters, Journal article 2016
Journal article

Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8.
Nallani Vijay Kumar, Jianbo Yang, Jitesh K Pillai, Swati Rawat, Carlos Solano et al.
Molecular and cellular biology, Journal article 2016
Journal article

Showing 11 - 20 of 81


Disentangling genetic and epigenetic determinants of ultrafast adaptation.
Arne B Gjuvsland, Enikö Zörgö, Jeevan Ka Samy, Simon Stenberg, Ibrahim H Demirsoy et al.
Molecular systems biology, Journal article 2016
Journal article


HwHog1 kinase activity is crucial for survival of Hortaea werneckii in extremely hyperosmolar environments.
Anja Kejžar, Morten Grøtli, Markus J. Tamás, Ana Plemenitaš, Metka Lenassi
Fungal genetics and biology : FG & B, Journal article 2015
Journal article


Mathematical modelling of arsenic transport, distribution and detoxification processes in yeast.
Soheil Rastgou Talemi, Therese Jacobson, Vijay Garla, Clara Navarrete, Annemarie Wagner et al.
Molecular Microbiology, Journal article 2014
Journal article

Elucidating the response of Kluyveromyces lactis to arsenite and peroxide stress and the role of the transcription factor KlYap8.
Jenny Veide Vilg, Nallani Vijay Kumar, Ewa Maciaszczyk-Dziubinska, Ewa Sloma, Djamila Onesime et al.
Biochimica et biophysica acta, Journal article 2014
Journal article

Showing 11 - 20 of 81

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