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John Fletcher

Senior lecturer

John Fletcher
Senior lecturer
john.fletcher@gu.se
+46 31 786 9105
0766-229105

Room number: 4032
Postal Address: Kemigården 4, 412 96 Göteborg
Visiting Address: Kemigården 4 , 412 96 Göteborg


Department of Chemistry & Molecular Biology (More Information)
Box 462
405 30 Göteborg
www.cmb.gu.se
inst.kmb@cmb.gu.se
Fax: +46 31 786 2599
Visiting Address: Medicinaregatan 9 C , 413 90 Göteborg

About John Fletcher

 

My groups research is focused on the development and application of imaging mass spectrometry for biological analysis. Mass spectrometry provides molecular specific chemical information without the need to incorporate exogenous labels. When used in an imaging modality this chemical precision is combined with precise spatial distribution. Secondary ion mass spectrometry (SIMS) uses a focused ion beam to probe the surface of a sample and the nature of the ion beam fired at the sample can ultimately determine what chemical species are detected in the mass spectrometer.
As there is a constant demand for more signal at higher resolution and so ion beam development is an active area of research particularly using new gas cluster ion beam technology. For biological sample analysis ensuring that the data generated is representative of the "live" sample means that methods to prepare and analyse biological specimen in the vacuum environment required for imaging SIMS are critical.
Combining the new ion beams with optimal sample preperation provides a route to identifying lipidomic changes on a sub-cellular scale, potentially in 3D, in order elucidate the underlying chemical processes involved in disease progression and treatment.

 

Current PhD students

Marwa Munem

Kelly Dimovska Nilsson 

Teaching and Departmental Responsibilities

KEM070 - Basic Analytical Chemistry

KEM081 - Advanced Analytical Chemistry

KEA310 - Introduction to Analytical Chemistry

Analytical Chemistry Project Contact

Coordinator of Chemistry Masters Program

Departmental Strategy Board Member

 

 

Latest publications

Mass Spectrometry Imaging and Integration with Other Imaging Modalities for Greater Molecular Understanding of Biological Tissues
T. P. Siegel, G. Hamm, J. Bunch, J. Cappell, John S. Fletcher et al.
Molecular Imaging and Biology, Review article 2018
Review article

Cholesterol Alters the Dynamics of Release in Protein Independent Cell Models for Exocytosis
Neda Najafinobar, Lisa J. Mellander, Michael E. Kurczy, Johan Dunevall, Tina B. Angerer et al.
Scientific Reports, Journal article 2016
Journal article

Showing 31 - 40 of 82

2014

Examination of fragment ions of polystyrene in TOF-SIMS spectra using MS/MS
T. Kawashima, T. Kurosawa, S. Aoyagi, S. Sheraz, John S. Fletcher et al.
Surface and Interface Analysis, Journal article 2014
Journal article

2013

Compositional characterisation of metallurgical grade silicon and porous silicon nanosponge particles
Edward G. Chadwick, N. V. V. Mogili, Colm O'Dwyer, Jimmy D. Moore, John S. Fletcher et al.
RSC Advances, Journal article 2013
Journal article

Cluster and polyatomic primary ion beams
John S. Fletcher, Christopher Szakal
ToF-SIMS: Materials Analysis by Mass Spectrometry, 2nd Ed., Chichester & Manchester, IM Publications LLP & Surface Spectra Ltd, Chapter in book 2013
Chapter in book

Peptide structural analysis using continuous Ar cluster and C60 ion beams
Satoka Aoyagi, John S. Fletcher, Sadia Sheraz, Tomoko Kawashima, Irma Berrueta Razo et al.
Analytical and Bioanalytical Chemistry, Journal article 2013
Journal article

Enhancing Secondary Ion Yields in Time of Flight-Secondary Ion Mass Spectrometry Using Water Cluster Primary Beams
Sadia Sheraz, Andrew Barber, John S. Fletcher, Nicholas P. Lockyer, John C. Vickerman
Analytical Chemistry, Journal article 2013
Journal article

Evaluating the challenges associated with time-of-fight secondary ion mass spectrometry for metabolomics using pure and mixed metabolites
John S. Fletcher, Helen L Kotze, Emily G. Armitage, Nicholas P Lockyer, John C. Vickerman
Metabolomics, Journal article 2013
Journal article

ToF-SIMS as a tool for metabolic profiling small biomolecules in cancer systems
Helen L. Kotze, Emily G. Armitage, John S. Fletcher, Alex Henderson, Kaye J. Williams et al.
Surface and Interface Analysis, Journal article 2013
Journal article

Time-of-flight SIMS as a novel approach to unlocking the hypoxic properties of cancer
Emily G Armitage, Helen L Kotze, John S. Fletcher, Kaye J Williams, Nicholas P. Lockyer et al.
Surface and Interface Analysis, Journal article 2013
Journal article

Peak picking as a pre-processing technique for imaging time of flight secondary ion mass spectrometry
Jimmy D. Moore, Alex Henderson, John S. Fletcher, Nicholas P. Lockyer, John C. Vickerman
Surface and Interface Analysis, Journal article 2013
Journal article

Showing 31 - 40 of 82

Page Manager: Katleen Burm|Last update: 9/20/2013
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