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Leif Eriksson


Leif Eriksson
+46 31 786 9117

Room number: 1405
Postal Address: Box 462, 40530 Göteborg
Visiting Address: Medicinaregatan 9c, Lundberg Lab, , 41390 Göteborg

Department of Chemistry & Molecular Biology (More Information)
Box 462
405 30 Göteborg
Fax: +46 31 786 2599
Visiting Address: Medicinaregatan 9 C , 413 90 Göteborg

About Leif Eriksson

Contact information: Lundberg Lab, Medicinareg. 9c, 40530 Göteborg; office 1405.



Theoretical biophysical chemistry in form of computer based modeling of various biochemical processes and systems. Our focus has for a long time related to DNA damage processes, cancer and drug design; often linked to radical and photochemistry. In recent years, we have explored increasingly larger systems, including diffusion across biological membranes, drug loaded liposomes, derivation of protein structures and studies of their mechanisms, modeling of protein-protein complexes, and development of new inhibitors in cancer treatment and as antibiotics. 

We utilize a wide range of methods in our research, from DFT and QM/MM to molecular dynamics simulations and bioinformatic tools such as VHTS/docking and homology modeling.

ResearcherID: D-1226-2012
ORCID: 0000-0001-5654-3109

Current research group: 1 researcher (Dr Anna Reymer), 4 Postdocs (Dr Antonio Carlesso, Dr Jalil Mahdizadeh, Dr Kevin Moreau, Dr Melissa Thomas), 2 PhD students (Sonali Chavan, Johanna Hörberg), and several Master students, visiting researchers and PhD students.



Mainly on the following courses:
General chemistry (KEM011)
Analytical pharmaceutical chemistry (KER210)
General pharmaceutical chemistry (KER220)
Basic Molecular Modeling (KEM552)



Vice head of department for research.
Reviewer in SNAC (Swedish National Allocations Comittee for Supercomputing).

Participates in H2020 MSCA-ITN project TRAIN-ERS.
Participates in H2020 MCSA-RISE projects VIDEC and INSPIRED.
Member of UGOT CARe (Center for Antibiotics Resistance Research).
Editorial Board Member in Scientific Reports (Nature Publ Grp)



Leif Eriksson studied Chemistry at Stockholm university and University of Sussex 1985-1988. He received his PhD in Quantum chemistry at  Uppsala Universitet (1992), followed by a postdoctoral fellowship from the Swedish research council VR (then 'NFR') to go to Dalhousie University, Canada, 92/93. He most recently comes from NUI Galway, Ireland, and holds the current professorship in physical chemistry at GU since 2011. He was awarded the 2017 Pedagogic price from the Science section of the Göta Student Union at University of Gothenburg.

Eriksson has published >270 peer reviewed research papers and some 20 review papers and book chapters, in the field of theoretical/computational (bio)chemistry. He holds the patents of a new pharmaceutical against skin cancer and for a new inhibitor of Vitmain A degradation, and is part owner of spin-out companies Santium Pharma, C26 Bioscience, and Cell Stress Discoveries. He is currently involved in the development of several new drugs, of which the first are in the patenting stage.

Latest publications

Peptidomimetic-based identification of FDA-approved compounds inhibiting IRE1 activity
D. Doultsinos, Antonio Carlesso, C. Chintha, J. C. Paton, A. W. Paton et al.
Febs Journal, Journal article 2020
Journal article

Oxygen Dependent Purine Lesions in Double-Stranded Oligodeoxynucleotides: Kinetic and Computational Studies Highlight the Mechanism for 5 ',8-Cyclopurine Formation
C. Chatgilialoglu, Leif A Eriksson, M. G. Krokidis, A. Masi, S. D. Wang et al.
Journal of the American Chemical Society, Journal article 2020
Journal article

Footprints of natural selection at the mannose-6-phosphate isomerase locus in barnacles
J. C. B. Nunez, P. A. Flight, K. B. Neil, S. Rong, Leif A Eriksson et al.
Proceedings of the National Academy of Sciences of the United States of America, Journal article 2020
Journal article

Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1
C. Chintha, Antonio Carlesso, A. M. Gorman, A. Samali, Leif A Eriksson
RSC Advances, Journal article 2020
Journal article

A new split-luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation
A. Tashakor, M. H-Dehkordi, E. O'Connell, S. G. Ganau, R. Gozalbes et al.
Febs Open Bio, Journal article 2019
Journal article

Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation
M. Maurel, J. Obacz, T. Avril, Y. P. Ding, O. Papadodima et al.
EMBO Molecular Medicine, Journal article 2019
Journal article

The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors
M. Mahameed, T. Wilhelm, O. Darawshi, A. Obiedat, W. S. Tommy et al.
Cell Death and Disease, Journal article 2019
Journal article

Showing 61 - 70 of 75


Antioxidant properties of beta-carotene isomers and their role in photosystems: insights from ab initio simulations
J. Cerezo, J. Zuniga, A. Bastida, A. Requena, J.P. Cerón-Carrasco et al.
Journal of Physical Chemistry A, Journal article 2012
Journal article

Comparison of the Mechanism of Deamination of 5,6-dihydro-5-methylcytosine with other cytosine derivatives
A. Grand, J. Cadet, Leif A Eriksson, V. Labet, N.L. Jorge et al.
Theoretical Chemistry accounts, Journal article 2012
Journal article

Stability and iron coordination in DNA adducts of Anthracycline based anti-cancer drugs
A. Eizaguirre, M. Yanez, Leif A Eriksson
Physical Chemistry Chemical Physics, Journal article 2012
Journal article

Cloning and Functional Studies of a Splice Variant of CYP26B1 Expressed in Vascular Cells
A. A. Elmabsout, A. Kumawat, P. Saenz-Mendez, O. Krivospitskaya, H. Savenstrand et al.
Plos One, Journal article 2012
Journal article

Characterization of Agonist Binding to His524 in the Estrogen Receptor α Ligand Binding Domain
L. Gao, Y. Tu, H. Ågren, Leif A Eriksson
Journal of Physical Chemistry B, Journal article 2012
Journal article

7-Nitro-4-(phenylthio)benzofurazan is a potent generator of superoxide and hydrogen peroxide
Erik V. Patridge, Emma S. E. Eriksson, Philip G. Penketh, Raymond P. Baumann, Rui Zhu et al.
Archives of Toxicology, Journal article 2012
Journal article

Homology models of human all-trans retinoic acid metabolizing enzymes CYP26B1 and CYP26B1 spliced-variant.
P. Saenz-Mendez, A.A. Elmabsout, H. Sävenstrand, M.K.A. Awadalla, Å. Strid et al.
Journal of Chemical Information and Modeling, Journal article 2012
Journal article

Showing 61 - 70 of 75

Page Manager: Katleen Burm|Last update: 9/20/2013

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Utskriftsdatum: 2020-08-04