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Markus Tamas

Professor

Markus Tamas
Professor , Head of Department
molecular biology/genetics/biochemistry/yeast
markus.tamas@cmb.gu.se
+46 31 786 2548
0733-732548

Room number: 1450
Postal Address: Box 462, 40530 Göteborg
Visiting Address: Medicinaregatan 9 c , 41390 Göteborg


Department of Chemistry & Molecular Biology (More Information)
Box 462
405 30 Göteborg
www.cmb.gu.se
inst.kmb@cmb.gu.se
Fax: +46 31 786 2599
Visiting Address: Medicinaregatan 9 C , 413 90 Göteborg

About Markus Tamas

Contact details: Lundberg Laboratory, Medicinaregatan 9, Room number 1415

 

RESEARCH

Molecular biology of metal toxicity and tolerance

Many metals endanger the environment and human health, but are also increasingly used as therapeutic agents for medical treatment. Yet, little is known about the molecular mechanisms causing metal toxicity or the mechanisms by which eukaryotic cells counteract toxicity and acquire tolerance.
To gain insights into metal action and cellular tolerance mechanisms, we use front-line tools in molecular biology, biochemistry, cell biology, chemical biology and functional genomics. We study (1) transport proteins through which metals enter or leave cells, (2) signal transduction and transcriptional regulatory mechanisms that cells use to sense and respond to metals, and (3) proteins and cellular processes that are targeted by metals. We use the model eukaryote Saccharomyces cerevisiae to explore fundamental aspects of metal biology and also as a heterologous expression system to study tolerance factors from other organisms such as plants and mammals.

Publications ResearcherID: www.researcherid.com/rid/E-8183-2010

Publications Google Scholar: scholar.google.se/citations

Research team: Stefanie Weber (PhD student), Joana Rodrigues (PhD student), Sansan Hua (PhD student), Emma Lorentzon (PhD student), Antonia Romero (postdoc)


TEACHING

  • Eukaryotic Molecular Microbiology (BIO440)
  • Molecular Microbiology (BIO277)
  • Cell biology (BIO900)

 

COMMISSIONS

  • Head of Department: Department of Chemistry and Molecular Biology

 

QUALIFICATIONS

Markus J. Tamás studied molecular biology and biochemistry in Lund (Sweden) and Liège (Belgium) and spent a year as a research scholar at the Public Health Research Institute in New York (USA). Markus completed his PhD at the Katholieke Universiteit Leuven (Belgium) in 1999 and then moved to Gothenburg. Markus was awarded an assistant professorship by the Swedish Research Council in 2003 and became professor in eukaryotic microbiology in 2010.

Latest publications

Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and toxicity
Stefanie Andersson, Joana Rodrigues, Antonia Romero, Sansan Hua, Xinxin Hao et al.
International Conference on Yeast Genetics and Molecular Biology, Gothenburg, Sweden, workshop presentation (2019), Conference contribution 2019
Conference contribution

Editorial: Molecular Mechanisms of Metalloid Transport, Toxicity and Tolerance.
Gerd Patrick Bienert, Markus J. Tamás
Frontiers in cell and developmental biology, Editorial letter 2018
Editorial letter

Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo.
Markus J. Tamás, Bruno Fauvet, Philipp Christen, Pierre Goloubinoff
Current genetics, Review article 2018
Review article

Metal and metalloids cause protein misfolding and aggregation
Stefanie Andersson, Therese Jacobson, Smriti Priya, Sandeep K. Sharma, Sofia Jakobsson et al.
International Conference on Yeast Genetics and Molecular Biology, Prague, Czech Republic, workshop presentation (2017), Conference contribution 2017
Conference contribution

Metal and metalloids cause protein misfolding and aggregation
Stefanie Andersson, Therese Jacobson, Smriti Priya, Sandeep K. Sharma, Sofia Jakobsson et al.
Gordon Research Conference on Stress Proteins in Growth, Development & Disease, Newry, USA, Poster (2017), Poster 2017
Poster

Cadmium Causes Misfolding and Aggregation of Cytosolic Proteins in Yeast.
Therese Jacobson, Smriti Priya, Sandeep K Sharma, Stefanie Andersson, Sofia Jakobsson et al.
Molecular and Cellular Biology, Journal article 2017
Journal article

Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8.
Nallani Vijay Kumar, Jianbo Yang, Jitesh K Pillai, Swati Rawat, Carlos Solano et al.
Molecular and cellular biology, Journal article 2016
Journal article

Disentangling genetic and epigenetic determinants of ultrafast adaptation.
Arne B Gjuvsland, Enikö Zörgö, Jeevan Ka Samy, Simon Stenberg, Ibrahim H Demirsoy et al.
Molecular systems biology, Journal article 2016
Journal article

The mitogen-activated protein kinase Slt2 modulates arsenite transport through the aquaglyceroporin Fps1.
Doryaneh Ahmadpour, Ewa Maciaszczyk-Dziubinska, Roja Babazadeh, Sita Dahal, Magdalena Migocka et al.
FEBS letters, Journal article 2016
Journal article

Showing 71 - 79 of 79

2003

Gis4p is a novel component of ion homeostasis in the yeast Saccharomyces cerevisiae
Tian Ye, X Bao, Markus J. Tamás, Stefan Hohmann
Yeast, Conference contribution 2003
Conference contribution

A short regulatory domain restricts glycerol transport through yeast Fps1p
Markus J. Tamás, Sara Karlgren, Roslyn M. Bill, J.M. Thevelein, Jan Rydström et al.
Yeast, Conference contribution 2003
Conference contribution

Cellular response to arsenic
Michael Thorsen, Markus J. Tamás
Yeast, Conference contribution 2003
Conference contribution

Transcriptional activation of metalloid tolerance genes in Saccharomyces cerevisiae requires the AP-1-like proteins Yap1p and Yap8p
Markus J. Tamás, Robert Wysocki, Dindial Ramotar
European Journal of Biochemistry, Conference contribution 2003
Conference contribution

Metalloid tolerance based on phytochelatins is not functionally equivalent to the arsenite transporter Acr3p.
Robert Wysocki, Stephan Clemens, Daria Augustyniak, Pawel Golik, Ewa Maciaszczyk et al.
Biochemical and biophysical research communications, Journal article 2003
Journal article

A Short Regulatory Domain Restricts Glycerol Transport through Yeast Fps1p
Markus J. Tamás, Sara Karlgren, Roslyn M. Bill, Kristina Hedfalk, L Allegri et al.
J. Biol. Chem, Journal article 2003
Journal article

1999

Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation.
Markus J. Tamás, K Luyten, F C Sutherland, A Hernandez, J Albertyn et al.
Molecular microbiology, Journal article 1999
Journal article

Showing 71 - 79 of 79

Page Manager: Katleen Burm|Last update: 9/20/2013
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