Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

John Fletcher

Senior lecturer

John Fletcher
Senior lecturer
john.fletcher@gu.se
+46 31 786 9105
0766-229105

Room number: 4032
Postal Address: Kemigården 4, 412 96 Göteborg
Visiting Address: Kemigården 4 , 412 96 Göteborg


Department of Chemistry & Molecular Biology (More Information)
Box 462
405 30 Göteborg
www.cmb.gu.se
inst.kmb@cmb.gu.se
Fax: +46 31 786 2599
Visiting Address: Medicinaregatan 9 C , 413 90 Göteborg

About John Fletcher

 

My groups research is focused on the development and application of imaging mass spectrometry for biological analysis. Mass spectrometry provides molecular specific chemical information without the need to incorporate exogenous labels. When used in an imaging modality this chemical precision is combined with precise spatial distribution. Secondary ion mass spectrometry (SIMS) uses a focused ion beam to probe the surface of a sample and the nature of the ion beam fired at the sample can ultimately determine what chemical species are detected in the mass spectrometer.
As there is a constant demand for more signal at higher resolution and so ion beam development is an active area of research particularly using new gas cluster ion beam technology. For biological sample analysis ensuring that the data generated is representative of the "live" sample means that methods to prepare and analyse biological specimen in the vacuum environment required for imaging SIMS are critical.
Combining the new ion beams with optimal sample preperation provides a route to identifying lipidomic changes on a sub-cellular scale, potentially in 3D, in order elucidate the underlying chemical processes involved in disease progression and treatment.

 

Current PhD students

Marwa Munem

Kelly Dimovska Nilsson 

Teaching and Departmental Responsibilities

KEM070 - Basic Analytical Chemistry

KEM081 - Advanced Analytical Chemistry

KEA310 - Introduction to Analytical Chemistry

Analytical Chemistry Project Contact

Coordinator of Chemistry Masters Program

Departmental Strategy Board Member

 

 

Latest publications

Mass Spectrometry Imaging and Integration with Other Imaging Modalities for Greater Molecular Understanding of Biological Tissues
T. P. Siegel, G. Hamm, J. Bunch, J. Cappell, John S. Fletcher et al.
Molecular Imaging and Biology, Review article 2018
Review article

Cholesterol Alters the Dynamics of Release in Protein Independent Cell Models for Exocytosis
Neda Najafinobar, Lisa J. Mellander, Michael E. Kurczy, Johan Dunevall, Tina B. Angerer et al.
Scientific Reports, Journal article 2016
Journal article

Showing 71 - 80 of 82

2006

A comparative study of secondary ion yield from model biological membranes using Au-n(+) and C-60(+) primary ion sources
M. J. Baker, John S. Fletcher, H. Jungnickel, N. P. Lockyer, J. C. Vickerman
Applied Surface Science, Elsevier, Conference paper 2006
Conference paper

ToF-SIMS studies of Bacillus using multivariate analysis with possible identification and taxonomic applications
C. E. Thompson, J. Ellis, John S. Fletcher, R. Goodacre, A. Henderson et al.
Applied Surface Science, Conference paper 2006
Conference paper

ToF-SIMS studies of Bacillus using multivariate analysis with possible identification and taxonomic applications
Charlotte E. Thompson, Joanne Ellis, John S. Fletcher, Goodacre Roy, Alex Henderson et al.
Applied Surface Science, Journal article 2006
Journal article

ToF-SIMS analysis of bio-systems: Are polyatomic primary ions the solution?
E. A. Jones, John S. Fletcher, C. E. Thompson, D. A. Jackson, N. P. Lockyer et al.
Applied Surface Science, Conference paper 2006
Conference paper

C-60, buckminsterfullerene: its impact on biological ToF-SIMS analysis
John S. Fletcher, Nicholas P. Lockyer, John C. Vickerman
Surface and Interface Analysis, Review article 2006
Review article

Molecular depth profiling of organic and biological materials
John S. Fletcher, Xavier A. Conlan, Nicholas P. Lockyer, John C. Vickerman
Applied Surface Science, Conference paper 2006
Conference paper

Rapid discrimination of the causal agents of urinary tract infection using ToF-SIMS with chemometric cluster analysis
John S. Fletcher, A. Henderson, R. M. Jarvis, N. P. Lockyer, J. C. Vickerman et al.
Applied Surface Science, Conference paper 2006
Conference paper

2004

ToF-SIMS Studies of Sulfuric Acid Hydrate Films
John S. Fletcher, Alex Henderson, Andrew B. Horn, John C. Vickerman
Journal of Physical Chemistry B, Journal article 2004
Journal article

ToF-SIMS analysis of atmospherically relevant sulphuric acid hydrate films and reactions thereof
John S. Fletcher, John C. Vickerman
Applied Surface Science, Journal article 2004
Journal article

2003

First detection of molecular hydrate complexes in sulfuric acid aerosols
SB Couling, John S. Fletcher, AB Horn, DA Newnham, RA McPheat et al.
Physical Chemistry Chemical Physics - PCCP, Journal article 2003
Journal article

Showing 71 - 80 of 82

Page Manager: Katleen Burm|Last update: 9/20/2013
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?