John Fletcher

Professor

Overview Publications UNDEFINED UNDEFINED UNDEFINED

John Fletcher
Professor
john.fletcher@chem.gu.se
+46 31 786 9105
0766-229105

Room number: 4032
Postal Address: Kemigården 4, 412 96 Göteborg
Visiting Address: Kemigården 4 , 412 96 Göteborg

Department of Chemistry & Molecular Biology (More Information)
Box 462
405 30 Göteborg
www.cmb.gu.se
inst.kmb@cmb.gu.se
Fax: +46 31 786 2599
Visiting Address: Medicinaregatan 9 C , 413 90 Göteborg

About John Fletcher

My groups research is focused on the development and application of imaging mass spectrometry for biological analysis. Mass spectrometry provides molecular specific chemical information without the need to incorporate exogenous labels. When used in an imaging modality this chemical precision is combined with precise spatial distribution. Secondary ion mass spectrometry (SIMS) uses a focused ion beam to probe the surface of a sample and the nature of the ion beam fired at the sample can ultimately determine what chemical species are detected in the mass spectrometer.
As there is a constant demand for more signal at higher resolution and so ion beam development is an active area of research particularly using new gas cluster ion beam technology. For biological sample analysis ensuring that the data generated is representative of the "live" sample means that methods to prepare and analyse biological specimen in the vacuum environment required for imaging SIMS are critical.
Combining the new ion beams with optimal sample preperation provides a route to identifying lipidomic changes on a sub-cellular scale, potentially in 3D, in order elucidate the underlying chemical processes involved in disease progression and treatment.

Current group members

Kelly Dimovska Nilsson

Ibrahim Kaya

Sanna Sämfors

Teaching and Departmental Responsibilities

KEM070 - Basic Analytical Chemistry

KEM081 - Advanced Analytical Chemistry

KEA310 - Introduction to Analytical Chemistry

Analytical Chemistry Project Contact

Coordinator of Chemistry Masters Program

Departmental Strategy Board Member

GOOGLE SCHOLAR

Research areas

Latest publications

Localised lipid accumulation detected in infarcted mouse heart tissue using ToF-SIMS
S. Samfors, Marcus Ståhlman, Martina Klevstig, Jan Borén, John S. Fletcher
International Journal of Mass Spectrometry, Journal article 2019
Journal article

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On-Tissue Chemical Derivatization of Catecholamines Using 4-(N-Methyl)pyridinium Boronic Acid for ToF-SIMS and LDI-ToF Mass Spectrometry Imaging
Ibrahim Kaya, S. M. Brülls, Johan Dunevall, Eva Jennische, Stefan Lange et al.
Analytical Chemistry, Journal article 2018
Journal article

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Mass Spectrometry Imaging and Integration with Other Imaging Modalities for Greater Molecular Understanding of Biological Tissues
T. P. Siegel, G. Hamm, J. Bunch, J. Cappell, John S. Fletcher et al.
Molecular Imaging and Biology, Review article 2018
Review article

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Benefits of NaCl addition for time-of-flight secondary ion mass spectrometry analysis including the discrimination of diacylglyceride and triacylglyceride ions
S. Samfors, Andrew G Ewing, John S. Fletcher
Rapid Communications in Mass Spectrometry, Journal article 2018
Journal article

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Mass Spectrometry Imaging Shows Cocaine and Methylphenidate Have Opposite Effects on Major Lipids in Drosophila Brain
Mai H. Philipsen, Nhu TN Phan, John S. Fletcher, Per Malmberg, Andrew G Ewing
Acs Chemical Neuroscience, Journal article 2018
Journal article

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Chemical imaging of aggressive basal cell carcinoma using time-of-flight secondary ion mass spectrometry
Marwa Munem, Oscar Zaar, Kelly Dimovska Nilsson, N. Neittaanmaki, John Paoli et al.
Biointerphases, Journal article 2018
Journal article

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MS/MS analysis and imaging of lipids across Drosophila brain using secondary ion mass spectrometry
Nhu TN Phan, Marwa Munem, Andrew G Ewing, John S. Fletcher
Analytical and Bioanalytical Chemistry, Journal article 2017
Journal article

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Lipid Heterogeneity Resulting from Fatty Acid Processing in the Human Breast Cancer Microenvironment Identified by GCIB-ToF-SIMS Imaging
Tina B. Angerer, Ylva Magnusson, Göran Landberg, John S. Fletcher
Analytical Chemistry, Journal article 2016
Journal article

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Multimodal Imaging of Chemically Fixed Cells in Preparation for NanoSIMS
Jelena Lovric, Per Malmberg, Bengt R Johansson, John S. Fletcher, Andrew G Ewing
Analytical Chemistry, Journal article 2016
Journal article

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Intact lipid imaging of mouse brain samples: MALDI, nanoparticle-laser desorption ionization, and 40 keV argon cluster secondary ion mass spectrometry
Amir Saeid Mohammadi, Nhu TN Phan, John S. Fletcher, Andrew G Ewing
Analytical and Bioanalytical Chemistry, Journal article 2016
Journal article

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Showing 81 - 83 of 83

2003

First detection of molecular hydrate complexes in sulfuric acid aerosols
SB Couling, John S. Fletcher, AB Horn, DA Newnham, RA McPheat et al.
Physical Chemistry Chemical Physics - PCCP, Journal article 2003
Journal article

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Identification of surface molecular hydrates on solid sulfuric acid films
SB Couling, KL Nash, John S. Fletcher, A Henderson, JC Vickerman et al.
Journal of the American Chemical Society, Journal article 2003
Journal article

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The role of surface molecular hydrates in the heterogeneous interaction of NH3 with sulfuric acid monohydrate
KL Nash, RM Sayer, SB Couling, John S. Fletcher, A Henderson et al.
Physical Chemistry Chemical Physics - PCCP, Journal article 2003
Journal article

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Showing 81 - 83 of 83

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Last update: 9/20/2013 10:37 AM

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