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John Fletcher


John Fletcher
+46 31 786 9105

Room number: 4032
Postal Address: Kemigården 4, 412 96 Göteborg
Visiting Address: Kemigården 4 , 412 96 Göteborg

Department of Chemistry & Molecular Biology (More Information)
Box 462
405 30 Göteborg
Fax: +46 31 786 2599
Visiting Address: Medicinaregatan 9 C , 413 90 Göteborg

About John Fletcher


My groups research is focused on the development and application of imaging mass spectrometry for biological analysis. Mass spectrometry provides molecular specific chemical information without the need to incorporate exogenous labels. When used in an imaging modality this chemical precision is combined with precise spatial distribution. Secondary ion mass spectrometry (SIMS) uses a focused ion beam to probe the surface of a sample and the nature of the ion beam fired at the sample can ultimately determine what chemical species are detected in the mass spectrometer.
As there is a constant demand for more signal at higher resolution and so ion beam development is an active area of research particularly using new gas cluster ion beam technology. For biological sample analysis ensuring that the data generated is representative of the "live" sample means that methods to prepare and analyse biological specimen in the vacuum environment required for imaging SIMS are critical.
Combining the new ion beams with optimal sample preperation provides a route to identifying lipidomic changes on a sub-cellular scale, potentially in 3D, in order elucidate the underlying chemical processes involved in disease progression and treatment.


Current group members

Kelly Dimovska Nilsson 

Ibrahim Kaya

Sanna Sämfors

Teaching and Departmental Responsibilities

KEM070 - Basic Analytical Chemistry

KEM081 - Advanced Analytical Chemistry

KEA310 - Introduction to Analytical Chemistry

Analytical Chemistry Project Contact

Coordinator of Chemistry Masters Program

Departmental Strategy Board Member




Latest publications

Mass Spectrometry Imaging and Integration with Other Imaging Modalities for Greater Molecular Understanding of Biological Tissues
T. P. Siegel, G. Hamm, J. Bunch, J. Cappell, John S. Fletcher et al.
Molecular Imaging and Biology, Review article 2018
Review article

Showing 81 - 87 of 87


Molecular depth profiling of organic and biological materials
John S. Fletcher, Xavier A. Conlan, Nicholas P. Lockyer, John C. Vickerman
Applied Surface Science, Conference paper 2006
Conference paper

Rapid discrimination of the causal agents of urinary tract infection using ToF-SIMS with chemometric cluster analysis
John S. Fletcher, A. Henderson, R. M. Jarvis, N. P. Lockyer, J. C. Vickerman et al.
Applied Surface Science, Conference paper 2006
Conference paper


ToF-SIMS Studies of Sulfuric Acid Hydrate Films
John S. Fletcher, Alex Henderson, Andrew B. Horn, John C. Vickerman
Journal of Physical Chemistry B, Journal article 2004
Journal article

ToF-SIMS analysis of atmospherically relevant sulphuric acid hydrate films and reactions thereof
John S. Fletcher, John C. Vickerman
Applied Surface Science, Journal article 2004
Journal article


First detection of molecular hydrate complexes in sulfuric acid aerosols
SB Couling, John S. Fletcher, AB Horn, DA Newnham, RA McPheat et al.
Physical Chemistry Chemical Physics - PCCP, Journal article 2003
Journal article

Identification of surface molecular hydrates on solid sulfuric acid films
SB Couling, KL Nash, John S. Fletcher, A Henderson, JC Vickerman et al.
Journal of the American Chemical Society, Journal article 2003
Journal article

The role of surface molecular hydrates in the heterogeneous interaction of NH3 with sulfuric acid monohydrate
KL Nash, RM Sayer, SB Couling, John S. Fletcher, A Henderson et al.
Physical Chemistry Chemical Physics - PCCP, Journal article 2003
Journal article

Showing 81 - 87 of 87

Page Manager: Katleen Burm|Last update: 9/20/2013

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