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Molecular anatomy of a new potassium channel variant associated with epilepsy

Research profile seminar

Voltage-gated potassium (KV) channels are membrane proteins that regulate electrical signaling in cells. Gene KCNA2 encodes KV1.2 channel subunits, expressed throughout the central nervous system. A new variant of KCNA2 was discovered in an infant with epilepsy, resulting in missense mutation KV1.2-F302L. Both gain and loss of KV function have been previously associated with epilepsy, so it was not possible to predict the effects on F302L on the structure, function, and biosynthesis of the channel; neither its effects on neuronal excitability. We used a multitude of experimental and computational techniques (electrophysiology, fluorescence spectroscopy, confocal microscopy, flow cytometry, molecular and neuronal simulations) to address the question: how does a point genomic lesion result in epilepsy?

Lecturer: Antonios Pantazis (https://liu.se/en/employee/antpa45)

Date: 12/5/2019

Time: 12:00 PM - 1:00 PM

Categories: Science

Location: Sal KC, Kemihuset, Campus Johanneberg

Contact person: Alesia Tietze

Page Manager: |Last update: 1/2/2012

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Utskriftsdatum: 2020-08-08