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- 2016 News - Archive

Research funding

The group recently received funding from the Carl Trygger foundation for installing an autocorrelation for pulse control in the optics lab.



Half-time seminar

Hanna Thomsen successfully presented her research project

"Two-photon excitation applied towards photoactivated processes in cellular and bacterial systems"

at the Half-time seminar, Wed Dec 7, 2016




PhD student position available!

We are looking for a PhD student in Biomedical photonics.
More info is found here: Available positions



Promotion - Senior Lecturer

Groupleader Marica B. Ericson was promoted to senior lecturer June 2016.



Johan now PhD

Johan Borglin successfully defended his thesis, Fri May 27 and is now PhD. Congratulations!

Thesis available on: GUPEA thesis



PhD defense

Johan Borglin will defend his thesis, Fri May 27 at 10 in KE

Title of thesis:

Multi-photon microscopy enhanced: Exploring annular beams and gold nano-particles for improved imaging

More info and thesis available on: Johan Borglin defense



PhD student position available!

We are looking for a PhD student in Biomedical photonics.
More info on: Available positions

(Note this position was withdrawn in Sept 2016. New adverticement is expected during fall 2016)

/2016-03-01 (update 2016-11-05)

Masters or Bachelors project?

We are presently looking for a Bachelors or Masters students.

More info on: Available positions



New publication!

Check out our most recent publication on Gold Nanoparticles and Multiphoton Induced Luminescence!

Link to publications!



Research grant!

The biomedical photonics group was awarded a four year research grant from the Swedish Research Council (VR) on the topic "Quantitative advanced optical microscopy and multiphoton lithography focusing on biomedical applications".



Do you want to help us out in the laser lab?

We are presently looking for a Bachelors or Masters student for Lab-view programming in our laser lab.

More info on: Available positions



Nobel Prize in Chemistry 2014

Superresolution fluorescence microscopy

Marica comments on the Nobel prize (Swedish): NEWS @ GU

More info on: Nobelprize.org



Licentiate seminar: Johan Borglin

"Exploring methods and applications for multi-photon microscopy"

Tuesday: 2014-10-14, 13:15

Luftbryggan, Institutionen för fysik

Opponent: Stefan Andersson-Engels, Lund University


Laser scanning multi-photon microscopy (MPM) is a powerful tool for non-invasive three-dimensional and of biological tissue. MPM operates in the near-infrared optical window, where the absorption in tissue is low. The localized region enables confocality without the use of a pinhole while providing less photobleaching and photodamage.

A limitation associated with multi-photon microscopy is the generation of out-of-focus fluorescence when imaging deeply in highly scattering tissue, which limits imaging depth. Annular laser beams have interesting properties, and could provide a way to reduce out-of-focus fluorescence. In this thesis, mathematical models have been implemented to investigate the potential of this technique. It could be concluded that illumination with annular beams provides a lower out-of-focus fluorescence than with Gaussian beams, while retaining the shape of the focal volume. In addition, an experimental MPM was set up and initial experiments were performed on a simple tissue phantom. This first proof-of-principle experiment demonstrates a reduction of out-of-focus fluorescence of 5%. Future work will be done to further reduce out-of-focus fluorescence by improving the set-up.

Multi-photon induced luminescence in gold nanoparticles was explored for use in multi-photon microscopy. Gold nanoparticles have previously been explored as contrast agents, and it is therefore important to understand the process by which they exhibit luminescence. The study was carried out using gold nano-particles deposited in a gradient, which were imaged using a commercial MPM setup with settings applicable to life sciences. It was concluded that 10 nm gold nano-spheres need to be clustered to be visible using a multi-photon microscope, which is important to take into account when working with this type of materials.

Keywords: Multi-photon microscopy, Annular beams,
Gold nanoparticles, Multi-photon induced luminescence



PhD defence: Vladimir Kirejev

Exploring nanosystems for biomedical applications focusing on photodynamic therapy and drug delivery

Wednesday: 2014-04-09, 09:15

Kollektorn, MC2, Kemivägen 9 (Chalmersområdet)

Link to thesis: https://gupea.ub.gu.se/handle/2077/35177




Biomedical photonics have identified targets of haptenation in human skin

Our work has been highlighted in Current Optinion in Immunology by Stefan F. Martin.
The first in vivo targets of haptenation in human skin were identified in an elegant study. Caged fluorescent haptens, thiol reactive bromobimanes, were used to detect target proteins in full thickness human skin 20 h after application using two photon fluorescence microscopy [Simonsson et al, 2011].

Martin, S.F., (2012), Allergic contact dermatitis: Xenoinflammation of the skin. Current Opinion in Immunology 24, 720-729.



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