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Gold nanoparticles for biomedical applications


Plasmonic noblemetal nanoparticles, particularly gold nanoparticles (AuNP), are presently explored for a wide variety of uses within the biological field, e.g. as contrast enhancers, or drug delivery devices [1-4]. The optical features of the nanoparticles are strongly dependent on their size and shape[2]. For example, AuNPs in the size 10 -20 nm exhibit a bandgap of 2.4 eV, which is not present for bulk gold. This is a quantum mechanics effect due to the band structure of AuNPs, giving rise to the characteristic color of the AuNPs in solution.

In our group we explore multiphoton induced luminescence as a tool to use AuNPs for biosensory applications. See more our recent publications:

  • Borglin, J., Selegard, R., Aili, D. & Ericson, M. B. Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast Medium in Multiphoton Microscopy. Nano Letters 17, 2102-2108 (2017).
  • Borglin, J. et al. Insights on proximity effect and multiphoton induced luminescence from gold nanospheres in far field optical microscopy. Applied Physics Letters 107, 234101-5 (2015).
     


 

References

1. Durr, N.J., et al., Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods. Nano Lett, 2007. 7(4): p. 941-5.
2. Daniel, M.C. and D. Astruc, Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev, 2004. 104(1): p. 293-346.
3. Sperling, R.A., et al., Biological applications of gold nanoparticles. Chem Soc Rev, 2008. 37(9): p. 1896-908.
4. Nicholas, D., E. Marica, and B.-Y. Adela, Multiphoton Luminescence from Gold Nanoparticles as a Potential Diagnostic Tool for Early Cancer Detection, in Biosensors and Molecular Technologies for Cancer Diagnostics. 2012, Taylor & Francis. p. 307-322.
 

 /2017-09-18

Page Manager: Katleen Burm|Last update: 9/18/2017
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http://cmb.gu.se/english/research/organic-and-medicinal-chemistry/Biomedical_Photonics/projects/gold-nanoparticles-/
Utskriftsdatum: 2019-07-16