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Beidong Liu

Universitetslektor

Beidong Liu
Universitetslektor
Akademisk grad: Docent,
lui.beidong@cmb.gu.se
031-786 2566

Rumsnummer: 1340
Postadress: Box 462, 40530 Göteborg
Besöksadress: Medicinaregatan 9C , 41390 Göteborg


Institutionen för kemi och molekylärbiologi (Mer information)
Box 462
405 30 Göteborg
www.cmb.gu.se
inst.kmb@cmb.gu.se
Fax: 031-786 2599
Besöksadress: Medicinaregatan 9 C , 413 90 Göteborg

Om Beidong Liu

Current position

Research

My present research interest is focused on deciphering mechanisms underlying aging-related diseases by developing and applying novel high-content screening techniques using yeast
 (Saccharomyces cerevisiae) as a model system. The powerful high throughput screening approach, developed in my group, enables me to study all the possible combinations between a phenotypic reporter of choice and a collection of gene mutants throughout the yeast genome in a few months (while a conventional manual test would take more than several decades). This approach makes it possible to pull out almost all components being part of any specific biological machinery and allows for an unbiased, genome-wide, identification of components and networks involved in, for example, protein quality control, protein aggregate formation and inheritance and epigenetic silencing.

Main ongoing research projects

  • 1. 2016-2019, Swedish Research Council (VR 2015-04984), Mechanisms controlling sequestration and detoxification of Huntingtin proteins in yeast (Saccharomyces cerevisiae).
  • 2. 2016-2017, Swedish Cancer Fund /Cancerfonden (CAN 2015/406), Identifying machineries and pathways controlling stress granule formation – roles in cancer initiation and progression.
  • 3. 2015-2016, Carl Trygger Foundation (CTS 14: 295), Deciphering machineries underlying protein inclusion body formation in yeast (Saccharomyces cerevisiae).
  • 4. MoRE (Marie Curie) fellow, 2015-2017, Marie Curie/Cofund Mobility for Regional Excellence (MoRE) fellowship. a mobility programme co-financed by the EU within the framework of the Fp7-People-COFUND programme.

Previous main research projects

  • 1. Deciphering machineries underlying thermal and disease protein induced inclusion body formation, 2012-2015, Swedish Research Council (VR 2011-5923)
  • 2. Global analysis of network control of epigenetic gene silencing regulation – potential role in age-related cancers, 2013-2015, Cancerfonden (CAN 2012/601)
  • 3. Deciphering human disease protein synphilin-1 induced inclusion body formation machineries in Saccharomyces cerevisiae, 2012-2014, Stiftelsen Olle Engkvist Byggmästare

Group members

Postdocs:

  • Xiuling Cao(main-supervisor), from 2015-08-03
  • Roja Babazadeh(co-superviser), from 2014-11-01
  • Lihua Chen(main-supervisor), from 2013-10-29
  • Doryaneh Ahmadpour (co-supervisor), from 2015-03-01

Ph.D. students:

  • Sansan Hua, from 2015-03-09 (main-supervisor)
  • Zheng Ju, from 2014-04-15 (main-supervisor)
  • Sandra Malmgren Hill, from 2012 (co-supervisor)

Permanent technician:

  • Xinxin Hao (Research assistant)

Permanent Staff of the Center for Large-scale cell-based screening:

  • Peter Dahl (Research engineer), Xinxin Hao (Research assistant)

Past lab members

  • Previous postdocs: Qian Liu (main-supervisor), from 2013-08-23 to 2015-08-23; Junsheng Yang (co-superviser), from 2011-09-01 to 2015-01-14
  • Zhao Lie, Ph.D. student; Song Jia, Ph.D.; Yang Xiaoxue, Ph.D.
  • Tom Lebacq, M.Sc.;Daniel Wiberg, M.Sc.;Eman Abbas, M.Sc.;Anna Barcons Simon, M.Sc.; Anna Sigurdsson, M.Sc.; Friederike Ewald, M.Sc.; Kathi Roempler, M.Sc.Daniel Höglund, M.Sc….

Teaching

Graduate level

  • Yeast genome-wide analysis and high content microscopy principles and basic skills, course developer and course leader.
  • Phenomics - from genotype to phenotype, main teacher.

Undergraduate level

  • Cell and Molecular Biology, 15hp (BIO213) , main teacher
  • Eukaryote molecular microbiology, 15hp (BIO440).
  • Bioinformatics and functional genomics (BIOFUN), 15hp (BIO210), main teacher.
  • Advanced Functional Genomics, 15hp (BIO406), main teacher.

 

Publikationsämnen

Senaste publikationer

Genome-wide analysis of Glycine soja ubiquitin (UBQ) genes and functional analysis of GsUBQ10 in response to alkaline stress
C. Chen, R. R. Chen, S. Y. Wu, D. Zhu, X. L. Sun et al.
Physiologia Plantarum, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

A Mitochondria-Associated Oxidative Stress Perspective on Huntington's Disease
Ju Zheng, J. Winderickx, V. Franssens, Beidong Liu
Frontiers in Molecular Neuroscience, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

GsSLAH3, a Glycine soja slow type anion channel homolog, positively modulates plant bicarbonate stress tolerance
X. B. Duan, Y. Yu, H. Duanmu, C. Chen, X. L. Sun et al.
Physiologia Plantarum, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

Genome-Wide Analysis of Glycine soja Response Regulator GsRR Genes Under Alkali and Salt Stresses
C. Chen, A. L. Liu, H. Ren, Y. Yu, H. Z. Duanmu et al.
Frontiers in Plant Science, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

Yeast as a Model to Unravel Mechanisms Behind FUS Toxicity in Amyotrophic Lateral Sclerosis
Michelle Lindström, Beidong Liu
Frontiers in Molecular Neuroscience, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

Genome-wide analysis and expression profiling of PP2C clade D under saline and alkali stresses in wild soybean and Arabidopsis
C. Chen, Y. Yu, X. D. Ding, Liu Beidong, H. Z. Duanmu et al.
Protoplasma, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

GsCHX19.3, a member of cation/H+ exchanger superfamily from wild soybean contributes to high salinity and carbonate alkaline tolerance
B. Jia, M. Sun, H. Duanmu, X. Ding, Liu Beidong et al.
Scientific Reports, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

The Glycine soja NAC transcription factor GsNAC019 mediates the regulation of plant alkaline tolerance and ABA sensitivity
L. Cao, Y. Yu, X. D. Ding, D. Zhu, F. Yang et al.
Plant Molecular Biology, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1
Ju Zheng, Junsheng Yang, Y. J. Choe, Xinxin Hao, Xiuling Cao et al.
Biochemical and Biophysical Research Communications, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Visar 1 - 10 av 33

2018

Genome-wide analysis of Glycine soja ubiquitin (UBQ) genes and functional analysis of GsUBQ10 in response to alkaline stress
C. Chen, R. R. Chen, S. Y. Wu, D. Zhu, X. L. Sun et al.
Physiologia Plantarum, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

A Mitochondria-Associated Oxidative Stress Perspective on Huntington's Disease
Ju Zheng, J. Winderickx, V. Franssens, Beidong Liu
Frontiers in Molecular Neuroscience, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

GsSLAH3, a Glycine soja slow type anion channel homolog, positively modulates plant bicarbonate stress tolerance
X. B. Duan, Y. Yu, H. Duanmu, C. Chen, X. L. Sun et al.
Physiologia Plantarum, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

Genome-Wide Analysis of Glycine soja Response Regulator GsRR Genes Under Alkali and Salt Stresses
C. Chen, A. L. Liu, H. Ren, Y. Yu, H. Z. Duanmu et al.
Frontiers in Plant Science, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

Yeast as a Model to Unravel Mechanisms Behind FUS Toxicity in Amyotrophic Lateral Sclerosis
Michelle Lindström, Beidong Liu
Frontiers in Molecular Neuroscience, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

Genome-wide analysis and expression profiling of PP2C clade D under saline and alkali stresses in wild soybean and Arabidopsis
C. Chen, Y. Yu, X. D. Ding, Liu Beidong, H. Z. Duanmu et al.
Protoplasma, Artikel i vetenskaplig tidskrift 2018
Artikel i vetenskaplig tidskrift

2017

GsCHX19.3, a member of cation/H+ exchanger superfamily from wild soybean contributes to high salinity and carbonate alkaline tolerance
B. Jia, M. Sun, H. Duanmu, X. Ding, Liu Beidong et al.
Scientific Reports, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

The Glycine soja NAC transcription factor GsNAC019 mediates the regulation of plant alkaline tolerance and ABA sensitivity
L. Cao, Y. Yu, X. D. Ding, D. Zhu, F. Yang et al.
Plant Molecular Biology, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1
Ju Zheng, Junsheng Yang, Y. J. Choe, Xinxin Hao, Xiuling Cao et al.
Biochemical and Biophysical Research Communications, Artikel i vetenskaplig tidskrift 2017
Artikel i vetenskaplig tidskrift

Visar 1 - 10 av 33

Sidansvarig: Katleen Burm|Sidan uppdaterades: 2016-06-20
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